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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

MSN

Gene description

Moesin

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most cell types. Highly abundant in lymphoid cells and endothelial cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

Supported based on 5 antibodies.
HPA000263 , HPA011135 , HPA011227 , CAB010898 , CAB047338
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA000263
HPA011135
HPA011227
CAB010898
CAB047338

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Liver, testis and urothelial cancers showed moderate cytoplasmic positivity. Remaining cancers were in general weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant lymphomas, melanomas, thyroid and skin cancers along with several malignant gliomas, ovarian, cervical and lung cancers showed weak to moderate membranous and cytoplasmic immunoreactivity. Remaining malignancies were in general negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignancies displayed mainly weak to moderate cytoplasmic and membranous immunoreactivity. Lymphomas and gliomas were generally negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant glioma, lymphoma and melanoma along with a few cases of liver, urothelial and endometrial cancers displayed weak to moderate cytoplasmic staining. Serous cystadenocarcinoma of ovary was moderately stained in the cytoplasmic membrane. Remaining malignant cells were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most of the cancer tissues displayed moderate to strong cytoplasmic positivity. Malignant carcinoids, gliomas, colorectal, breast, prostate and gastric cancers were weakly stained or negative.

GENE INFORMATION

Gene name

MSN

Synonyms

Description

Moesin (HGNC Symbol)

Entrez gene summary

Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

q12

Chromosome location (bp)

65588377 - 65741931

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000147065 (version 83.38)

Entrez gene

4478

UniProt

P26038 (UniProt - Evidence at protein level)

neXtProt

NX_P26038

Antibodypedia

MSN antibodies

PROTEIN BROWSER

MSN-001
MSN-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MSN-001
ENSP00000353408
ENST00000360270
P26038 [Direct mapping]
Moesin
V9HWC0 [Target identity:100%; Query identity:100%]
Epididymis luminal protein 70; Moesin, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001931 [uropod]
GO:0003725 [double-stranded RNA binding]
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0008361 [regulation of cell size]
GO:0010628 [positive regulation of gene expression]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0019901 [protein kinase binding]
GO:0022612 [gland morphogenesis]
GO:0022614 [membrane to membrane docking]
GO:0030175 [filopodium]
GO:0031143 [pseudopodium]
GO:0031528 [microvillus membrane]
GO:0031982 [vesicle]
GO:0043209 [myelin sheath]
GO:0045177 [apical part of cell]
GO:0045198 [establishment of epithelial cell apical/basal polarity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050839 [cell adhesion molecule binding]
GO:0050900 [leukocyte migration]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071394 [cellular response to testosterone stimulus]
GO:0071803 [positive regulation of podosome assembly]
GO:0071944 [cell periphery]
GO:0072562 [blood microparticle]
GO:1902115 [regulation of organelle assembly]
GO:1902966 [positive regulation of protein localization to early endosome]
GO:1903364 [positive regulation of cellular protein catabolic process]
GO:2000401 [regulation of lymphocyte migration]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
577 aa
67.8 kDa
No 0
MSN-003
ENSP00000477441
ENST00000609672
V9GZ54 [Direct mapping]
Moesin
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
Show all
103 aa
12.1 kDa
No 0

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