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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CRH

Gene description

Corticotropin releasing hormone

Protein class

Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (urothelial cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enhanced (cerebral cortex, placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.

Reliability score

Uncertain based on 2 antibodies.
HPA062111 , CAB010885
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (urothelial cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA062111
CAB010885

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Most cancer tissues showed weak to moderate cytoplasmic and nuclear staining. Few cases of colorectal and renal cancers displayed additional membranous positivity. Few cases of melanomas exhibited strong cytoplasmic immunoreactivity. Lymphomas were negative.

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Most malignancies showed moderate cytoplasmic positivity often accompanied with nucelar staining. The majority of liver and pancreatic cancers along with several malignant melanomas, testicular and gastric cancers were strongly stained.

GENE INFORMATION

Gene name

CRH (HGNC Symbol)

Synonyms

CRF, CRH1

Description

Corticotropin releasing hormone (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Nov 2015]

Chromosome

8

Cytoband

q13.1

Chromosome location (bp)

66176382 - 66178725

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000147571 (version 83.38)

Entrez gene

1392

UniProt

P06850 (UniProt - Evidence at protein level)

neXtProt

NX_P06850

Antibodypedia

CRH antibodies

PROTEIN BROWSER

CRH-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CRH-001
ENSP00000276571
ENST00000276571
P06850 [Direct mapping]
Corticoliberin
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001934 [positive regulation of protein phosphorylation]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006704 [glucocorticoid biosynthetic process]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007565 [female pregnancy]
GO:0007567 [parturition]
GO:0007611 [learning or memory]
GO:0008202 [steroid metabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0008306 [associative learning]
GO:0008628 [hormone-mediated apoptotic signaling pathway]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010700 [negative regulation of norepinephrine secretion]
GO:0010841 [positive regulation of circadian sleep/wake cycle, wakefulness]
GO:0010942 [positive regulation of cell death]
GO:0014062 [regulation of serotonin secretion]
GO:0016101 [diterpenoid metabolic process]
GO:0021854 [hypothalamus development]
GO:0030324 [lung development]
GO:0030325 [adrenal gland development]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0032811 [negative regulation of epinephrine secretion]
GO:0033685 [negative regulation of luteinizing hormone secretion]
GO:0035641 [locomotory exploration behavior]
GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0035902 [response to immobilization stress]
GO:0042220 [response to cocaine]
GO:0042322 [negative regulation of circadian sleep/wake cycle, REM sleep]
GO:0042493 [response to drug]
GO:0043025 [neuronal cell body]
GO:0043196 [varicosity]
GO:0043204 [perikaryon]
GO:0043627 [response to estrogen]
GO:0045471 [response to ethanol]
GO:0045472 [response to ether]
GO:0045776 [negative regulation of blood pressure]
GO:0048265 [response to pain]
GO:0050801 [ion homeostasis]
GO:0051412 [response to corticosterone]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
GO:0051431 [corticotropin-releasing hormone receptor 2 binding]
GO:0051461 [positive regulation of corticotropin secretion]
GO:0051464 [positive regulation of cortisol secretion]
GO:0060291 [long-term synaptic potentiation]
GO:0060456 [positive regulation of digestive system process]
GO:0060548 [negative regulation of cell death]
GO:0070093 [negative regulation of glucagon secretion]
GO:0071314 [cellular response to cocaine]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0090280 [positive regulation of calcium ion import]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
GO:2000854 [positive regulation of corticosterone secretion]
GO:2000987 [positive regulation of behavioral fear response]
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196 aa
21.4 kDa
Yes 0

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