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CRH

GENERAL INFORMATION

Gene name

 CRH

Gene description

 Corticotropin releasing hormone

Protein class

 Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, placenta)
GTEx:Group enriched (cerebral cortex, hypothalamus)
FANTOM5:Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA062111 , CAB010885
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)

GENE INFORMATION

Gene name

 CRH (HGNC Symbol)

Synonyms

 CRF, CRH1

Description

 Corticotropin releasing hormone (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Nov 2015]

Chromosome

 8

Cytoband

 q13.1

Chromosome location (bp)

 66176382 - 66178725

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147571 (version 83.38)

Entrez gene

 1392

UniProt

 P06850 (UniProt - Evidence at protein level)

neXtProt

 NX_P06850

Antibodypedia

 CRH antibodies

PROTEIN BROWSER
CRH-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CRH-001
ENSP00000276571
ENST00000276571
P06850 [Direct mapping]
Corticoliberin
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006704 [glucocorticoid biosynthetic process]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007565 [female pregnancy]
GO:0007567 [parturition]
GO:0007611 [learning or memory]
GO:0008202 [steroid metabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0008306 [associative learning]
GO:0008628 [hormone-mediated apoptotic signaling pathway]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010700 [negative regulation of norepinephrine secretion]
GO:0010841 [positive regulation of circadian sleep/wake cycle, wakefulness]
GO:0010942 [positive regulation of cell death]
GO:0014062 [regulation of serotonin secretion]
GO:0016101 [diterpenoid metabolic process]
GO:0021854 [hypothalamus development]
GO:0030324 [lung development]
GO:0030325 [adrenal gland development]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0032811 [negative regulation of epinephrine secretion]
GO:0033685 [negative regulation of luteinizing hormone secretion]
GO:0035641 [locomotory exploration behavior]
GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0035902 [response to immobilization stress]
GO:0042220 [response to cocaine]
GO:0042322 [negative regulation of circadian sleep/wake cycle, REM sleep]
GO:0042493 [response to drug]
GO:0043025 [neuronal cell body]
GO:0043196 [varicosity]
GO:0043204 [perikaryon]
GO:0043627 [response to estrogen]
GO:0045471 [response to ethanol]
GO:0045472 [response to ether]
GO:0045776 [negative regulation of blood pressure]
GO:0048265 [response to pain]
GO:0050801 [ion homeostasis]
GO:0051412 [response to corticosterone]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
GO:0051431 [corticotropin-releasing hormone receptor 2 binding]
GO:0051461 [positive regulation of corticotropin secretion]
GO:0051464 [positive regulation of cortisol secretion]
GO:0060291 [long-term synaptic potentiation]
GO:0060456 [positive regulation of digestive system process]
GO:0060548 [negative regulation of cell death]
GO:0070093 [negative regulation of glucagon secretion]
GO:0071314 [cellular response to cocaine]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0090280 [positive regulation of calcium ion import]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
GO:2000854 [positive regulation of corticosterone secretion]
GO:2000987 [positive regulation of behavioral fear response]
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 196 aa
21.4 kDa 		Yes 0

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