Cell atlas - HERC4 - The Human Protein Atlas

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HERC4

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli fibrillar center

Human cell
	Cytosol
	Nucleoli

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GENERAL INFORMATION
Gene name	HERC4
Gene description	HECT and RLD domain containing E3 ubiquitin protein ligase 4
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the nucleoli (fibrillar center).
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Additional location	In addition localized to the Nucleoli fibrillar center (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA070301
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the nucleoli (fibrillar center).

Main location

Cytosol (supported)

Additional location

Nucleoli fibrillar center (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA070301	A-431	Nucleoli fibrillar center
	HPA070301	A-431	Cytosol
	HPA070301	BJ	Nucleoli fibrillar center
	HPA070301	BJ	Cytosol
	HPA070301	U-2 OS	Nucleoli fibrillar center
	HPA070301	U-2 OS	Cytosol

GENE INFORMATION
Gene name	HERC4 (HGNC Symbol)
Synonyms	DKFZP564G092, KIAA1593
Description	HECT and RLD domain containing E3 ubiquitin protein ligase 4 (HGNC Symbol)
Entrez gene summary	HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]
Chromosome	10
Cytoband	q21.3
Chromosome location (bp)	67921899 - 68075348
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148634 (version 83.38)
Entrez gene	26091
UniProt	Q5GLZ8 (UniProt - Evidence at protein level)
neXtProt	NX_Q5GLZ8
Antibodypedia	HERC4 antibodies

PROTEIN BROWSER

HERC4-001	HERC4-002	HERC4-006	HERC4-008	HERC4-009	HERC4-013	HERC4-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HERC4-001 ENSP00000362804 ENST00000373700	Q5GLZ8 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC4 A0A024QZN8 [Target identity:100%; Query identity:100%] Hect domain and RLD 4, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007283 [spermatogenesis] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0030154 [cell differentiation] GO:0061630 [ubiquitin protein ligase activity] Show all	1049 aa 117.7 kDa	No	1
HERC4-002 ENSP00000277817 ENST00000277817	Q5GLZ8 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007283 [spermatogenesis] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0030154 [cell differentiation] GO:0061630 [ubiquitin protein ligase activity] Show all	947 aa 106.7 kDa	No	1
HERC4-006 ENSP00000422383 ENST00000492996	Q5GLZ8 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC4 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007283 [spermatogenesis] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0030154 [cell differentiation] GO:0061630 [ubiquitin protein ligase activity] Show all	110 aa 12 kDa	No	0
HERC4-008 ENSP00000416504 ENST00000412272	Q5GLZ8 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC4 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007283 [spermatogenesis] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0030154 [cell differentiation] GO:0061630 [ubiquitin protein ligase activity] Show all	979 aa 109.6 kDa	No	0
HERC4-009 ENSP00000378624 ENST00000395198	Q5GLZ8 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007283 [spermatogenesis] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0030154 [cell differentiation] GO:0061630 [ubiquitin protein ligase activity] Show all	1057 aa 118.6 kDa	No	1
HERC4-013 ENSP00000426563 ENST00000506515	D6RFK9 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		29 aa 3.1 kDa	No	0
HERC4-015 ENSP00000427191 ENST00000513996	D6RCL5 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC4 Show all	TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		240 aa 25.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.