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HERC4

GENERAL INFORMATION

Gene name

 HERC4

Gene description

 HECT and RLD domain containing E3 ubiquitin protein ligase 4

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification. Pending retesting.

Reliability score

 Uncertain based on 1 antibody.
HPA045453
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045453

GENE INFORMATION

Gene name

 HERC4 (HGNC Symbol)

Synonyms

 DKFZP564G092, KIAA1593

Description

 HECT and RLD domain containing E3 ubiquitin protein ligase 4 (HGNC Symbol)

Entrez gene summary

 HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

Chromosome

 10

Cytoband

 q21.3

Chromosome location (bp)

 67921899 - 68075348

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148634 (version 83.38)

Entrez gene

 26091

UniProt

 Q5GLZ8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5GLZ8

Antibodypedia

 HERC4 antibodies

PROTEIN BROWSER
HERC4-001
HERC4-002
HERC4-006
HERC4-008
HERC4-009
HERC4-013
HERC4-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HERC4-001
ENSP00000362804
ENST00000373700
Q5GLZ8 [Direct mapping]
Probable E3 ubiquitin-protein ligase HERC4
A0A024QZN8 [Target identity:100%; Query identity:100%]
Hect domain and RLD 4, isoform CRA_b
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007283 [spermatogenesis]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0030154 [cell differentiation]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 1049 aa
117.7 kDa 		No 1
HERC4-002
ENSP00000277817
ENST00000277817
Q5GLZ8 [Direct mapping]
Probable E3 ubiquitin-protein ligase HERC4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007283 [spermatogenesis]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0030154 [cell differentiation]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 947 aa
106.7 kDa 		No 1
HERC4-006
ENSP00000422383
ENST00000492996
Q5GLZ8 [Direct mapping]
Probable E3 ubiquitin-protein ligase HERC4
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007283 [spermatogenesis]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0030154 [cell differentiation]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 110 aa
12 kDa 		No 0
HERC4-008
ENSP00000416504
ENST00000412272
Q5GLZ8 [Direct mapping]
Probable E3 ubiquitin-protein ligase HERC4
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007283 [spermatogenesis]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0030154 [cell differentiation]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 979 aa
109.6 kDa 		No 0
HERC4-009
ENSP00000378624
ENST00000395198
Q5GLZ8 [Direct mapping]
Probable E3 ubiquitin-protein ligase HERC4
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007283 [spermatogenesis]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0030154 [cell differentiation]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 1057 aa
118.6 kDa 		No 1
HERC4-013
ENSP00000426563
ENST00000506515
D6RFK9 [Direct mapping]
Probable E3 ubiquitin-protein ligase HERC4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 29 aa
3.1 kDa 		No 0
HERC4-015
ENSP00000427191
ENST00000513996
D6RCL5 [Direct mapping]
Probable E3 ubiquitin-protein ligase HERC4
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   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 240 aa
25.9 kDa 		No 0

Contact

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.