The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Moderate nuclear staining was observed in a fraction of cells, presumably in active cells. Strong positivity was observed in gastrointestinal glands, trophoblastic cells, germinal center cells of lymphoid tissues and basal cells in squamous epithelium. Remaining normal tissues were generally negative.
A subset of hematopoietic cells, squamous epithelia, duodenum and the lymphoid tissues showed moderate nuclear positivity. Breast, salivary gland, seminal vesicle and urothelium, gallbladder, bile duct cells, cardiac myocytes and pneumocytes exhibited moderate membranous and/or cytoplasmic staining.
Remaining normal tissues were in general negative.
Moderate to strong nuclear positivity was displayed in leukocytes in several tissues, in hematopoietic cells, in a large subset of cells in stratum spinosum of most squamous epithelia, subsets of cells in seminiferous ducts, and in small fractions of glandular cells in female genitalia. Most remaining cells were negative.
Germinal center cells along with subset of cells in squamous epithelium, intestinal glands, non-germinal center cells and cells in red pulp showed strong nuclear positivity. Strong cytoplasmic positivity was observed in subset of renal tubules. Thyroid was moderately stained. Remaining normal tissues were weakly stained or negative.