Cell atlas - INA - The Human Protein Atlas

GENERAL INFORMATION
Gene name	INA
Gene description	Internexin neuronal intermediate filament protein, alpha
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear membrane & intermediate filaments. In addition localized to the nucleoplasm.
RNA cell category	Cell line enhanced (SCLC-21H, SiHa, SH-SY5Y, NTERA-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (approved), Intermediate filaments (supported)
Additional location	In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA008057
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, SiHa, SH-SY5Y, NTERA-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear membrane & intermediate filaments. In addition localized to the nucleoplasm.

Main location

Nuclear membrane (approved), Intermediate filaments (supported)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA008057	A549	Nucleoplasm
		Nuclear membrane
		Intermediate filaments
HPA008057	SiHa	Nucleoplasm
		Nuclear membrane
		Intermediate filaments

GENE INFORMATION
Gene name	INA (HGNC Symbol)
Synonyms	NEF5, NF-66
Description	Internexin neuronal intermediate filament protein, alpha (HGNC Symbol)
Entrez gene summary	Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009]
Chromosome	10
Cytoband	q24.33
Chromosome location (bp)	103277163 - 103290351
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148798 (version 83.38)
Entrez gene	9118
UniProt	Q16352 (UniProt - Evidence at protein level)
neXtProt	NX_Q16352
Antibodypedia	INA antibodies

PROTEIN BROWSER

INA-001	INA-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INA-001 ENSP00000358865 ENST00000369849	Q16352 [Direct mapping] Alpha-internexin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005882 [intermediate filament] GO:0005883 [neurofilament] GO:0021762 [substantia nigra development] GO:0030154 [cell differentiation] GO:0031965 [nuclear membrane] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0043209 [myelin sheath] GO:0045104 [intermediate filament cytoskeleton organization] GO:0045111 [intermediate filament cytoskeleton] GO:0060052 [neurofilament cytoskeleton organization] Show all	499 aa 55.4 kDa	No	0
INA-201 ENSP00000481793 ENST00000616853	A0A087WYG8 [Direct mapping] Alpha-internexin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] GO:0005883 [neurofilament] GO:0007399 [nervous system development] Show all	496 aa 55.1 kDa	No	0