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INA

GENERAL INFORMATION

Gene name

 INA

Gene description

 Internexin neuronal intermediate filament protein, alpha

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (testis cancer)
HPA (cell line):Cell line enhanced (NTERA-2, SCLC-21H, SH-SY5Y, SiHa)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct expression in the CNS and in a subset of adrenal gland cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA008057 , CAB002059
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA008057
CAB002059

GENE INFORMATION

Gene name

 INA (HGNC Symbol)

Synonyms

 NEF5, NF-66

Description

 Internexin neuronal intermediate filament protein, alpha (HGNC Symbol)

Entrez gene summary

 Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009]

Chromosome

 10

Cytoband

 q24.33

Chromosome location (bp)

 103277163 - 103290351

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148798 (version 83.38)

Entrez gene

 9118

UniProt

 Q16352 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16352

Antibodypedia

 INA antibodies

PROTEIN BROWSER
INA-001
INA-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
INA-001
ENSP00000358865
ENST00000369849
Q16352 [Direct mapping]
Alpha-internexin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005882 [intermediate filament]
GO:0005883 [neurofilament]
GO:0021762 [substantia nigra development]
GO:0030154 [cell differentiation]
GO:0031965 [nuclear membrane]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0043209 [myelin sheath]
GO:0045104 [intermediate filament cytoskeleton organization]
GO:0045111 [intermediate filament cytoskeleton]
GO:0060052 [neurofilament cytoskeleton organization]
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 499 aa
55.4 kDa 		No 0
INA-201
ENSP00000481793
ENST00000616853
A0A087WYG8 [Direct mapping]
Alpha-internexin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
GO:0005883 [neurofilament]
GO:0007399 [nervous system development]
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 496 aa
55.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.