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CHEK1

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GENERAL INFORMATION

Gene name

 CHEK1

Gene description

 Checkpoint kinase 1

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to vesicles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved)

Additional location

 In addition localized to the Vesicles (approved)

Mouse

 Localized to the Nucleus in mouse cells.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA044364
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to vesicles.

Main location

 Nucleoplasm (approved)

Additional location

 Vesicles (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA044364 HEK 293 Nucleoplasm
Vesicles
HPA044364 MCF7 Nucleoplasm
HPA044364 U-2 OS Nucleoplasm

MOUSE CELLS

Main location

 Nucleus

Additional location

 Cytosol

Mouse gene

 ENSMUSG00000032113 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA044364 NIH 3T3 Nucleus
Cytosol

GENE INFORMATION

Gene name

 CHEK1 (HGNC Symbol)

Synonyms

 CHK1

Description

 Checkpoint kinase 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 11

Cytoband

 q24.2

Chromosome location (bp)

 125625136 - 125676255

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000149554 (version 83.38)

Entrez gene

 1111

UniProt

 O14757 (UniProt - Evidence at protein level)

neXtProt

 NX_O14757

Antibodypedia

 CHEK1 antibodies

PROTEIN BROWSER
«
CHEK1-001
CHEK1-002
CHEK1-004
CHEK1-005
CHEK1-006
CHEK1-007
CHEK1-008
CHEK1-009
CHEK1-010
CHEK1-011
CHEK1-012
CHEK1-013
CHEK1-201
CHEK1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHEK1-001
ENSP00000391090
ENST00000427383
E7EPP6 [Direct mapping]
Serine/threonine-protein kinase Chk1
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006468 [protein phosphorylation]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 492 aa
55.5 kDa 		No 0
CHEK1-002
ENSP00000412504
ENST00000428830
O14757 [Direct mapping]
Serine/threonine-protein kinase Chk1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0000794 [condensed nuclear chromosome]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0010569 [regulation of double-strand break repair via homologous recombination]
GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0031572 [G2 DNA damage checkpoint]
GO:0035402 [histone kinase activity (H3-T11 specific)]
GO:0035407 [histone H3-T11 phosphorylation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045839 [negative regulation of mitotic nuclear division]
GO:0046602 [regulation of mitotic centrosome separation]
GO:0048096 [chromatin-mediated maintenance of transcription]
GO:0071260 [cellular response to mechanical stimulus]
GO:0090399 [replicative senescence]
GO:2000615 [regulation of histone H3-K9 acetylation]
Show all
 476 aa
54.4 kDa 		No 0
CHEK1-004
ENSP00000435371
ENST00000534070
O14757 [Direct mapping]
Serine/threonine-protein kinase Chk1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0000794 [condensed nuclear chromosome]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0010569 [regulation of double-strand break repair via homologous recombination]
GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0031572 [G2 DNA damage checkpoint]
GO:0035402 [histone kinase activity (H3-T11 specific)]
GO:0035407 [histone H3-T11 phosphorylation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045839 [negative regulation of mitotic nuclear division]
GO:0046602 [regulation of mitotic centrosome separation]
GO:0048096 [chromatin-mediated maintenance of transcription]
GO:0071260 [cellular response to mechanical stimulus]
GO:0090399 [replicative senescence]
GO:2000615 [regulation of histone H3-K9 acetylation]
Show all
 476 aa
54.4 kDa 		No 0
CHEK1-005
ENSP00000442317
ENST00000544373
O14757 [Direct mapping]
Serine/threonine-protein kinase Chk1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0000794 [condensed nuclear chromosome]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0010569 [regulation of double-strand break repair via homologous recombination]
GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0031572 [G2 DNA damage checkpoint]
GO:0035402 [histone kinase activity (H3-T11 specific)]
GO:0035407 [histone H3-T11 phosphorylation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045839 [negative regulation of mitotic nuclear division]
GO:0046602 [regulation of mitotic centrosome separation]
GO:0048096 [chromatin-mediated maintenance of transcription]
GO:0071260 [cellular response to mechanical stimulus]
GO:0090399 [replicative senescence]
GO:2000615 [regulation of histone H3-K9 acetylation]
Show all
 382 aa
43.7 kDa 		No 0
CHEK1-006
ENSP00000278916
ENST00000278916
J3KN87 [Direct mapping]
Serine/threonine-protein kinase Chk1
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006468 [protein phosphorylation]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 432 aa
49 kDa 		No 0
CHEK1-007
ENSP00000432890
ENST00000524737
O14757 [Direct mapping]
Serine/threonine-protein kinase Chk1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0000794 [condensed nuclear chromosome]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0010569 [regulation of double-strand break repair via homologous recombination]
GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0031572 [G2 DNA damage checkpoint]
GO:0035402 [histone kinase activity (H3-T11 specific)]
GO:0035407 [histone H3-T11 phosphorylation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045839 [negative regulation of mitotic nuclear division]
GO:0046602 [regulation of mitotic centrosome separation]
GO:0048096 [chromatin-mediated maintenance of transcription]
GO:0071260 [cellular response to mechanical stimulus]
GO:0090399 [replicative senescence]
GO:2000615 [regulation of histone H3-K9 acetylation]
Show all
 476 aa
54.4 kDa 		No 0
CHEK1-008
ENSP00000432470
ENST00000534685
E9PQW7 [Direct mapping]
Serine/threonine-protein kinase Chk1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 127 aa
14.4 kDa 		No 0
CHEK1-009
ENSP00000433103
ENST00000533778
E9PM65 [Direct mapping]
Serine/threonine-protein kinase Chk1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 42 aa
4.6 kDa 		No 0
CHEK1-010
ENSP00000431815
ENST00000526937
E9PJI4 [Direct mapping]
Serine/threonine-protein kinase Chk1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 170 aa
19.5 kDa 		No 0
CHEK1-011
ENSP00000431525
ENST00000527013
E9PKQ3 [Direct mapping]
Serine/threonine-protein kinase Chk1
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 204 aa
23.3 kDa 		No 0
CHEK1-012
ENSP00000477588
ENST00000531607
A0A087WT52 [Direct mapping]
Serine/threonine-protein kinase Chk1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 111 aa
12.9 kDa 		No 0
CHEK1-013
ENSP00000434646
ENST00000532669
E9PPA5 [Direct mapping]
Serine/threonine-protein kinase Chk1
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 192 aa
22.2 kDa 		No 0
CHEK1-201
ENSP00000388648
ENST00000438015
O14757 [Direct mapping]
Serine/threonine-protein kinase Chk1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0000794 [condensed nuclear chromosome]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0010468 [regulation of gene expression]
GO:0010569 [regulation of double-strand break repair via homologous recombination]
GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0031572 [G2 DNA damage checkpoint]
GO:0035402 [histone kinase activity (H3-T11 specific)]
GO:0035407 [histone H3-T11 phosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045839 [negative regulation of mitotic nuclear division]
GO:0046602 [regulation of mitotic centrosome separation]
GO:0048096 [chromatin-mediated maintenance of transcription]
GO:0071260 [cellular response to mechanical stimulus]
GO:0090399 [replicative senescence]
GO:2000615 [regulation of histone H3-K9 acetylation]
Show all
 476 aa
54.4 kDa 		No 0
CHEK1-202
ENSP00000481616
ENST00000532449
O14757 [Direct mapping]
Serine/threonine-protein kinase Chk1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0000794 [condensed nuclear chromosome]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0010569 [regulation of double-strand break repair via homologous recombination]
GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0031572 [G2 DNA damage checkpoint]
GO:0035402 [histone kinase activity (H3-T11 specific)]
GO:0035407 [histone H3-T11 phosphorylation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045839 [negative regulation of mitotic nuclear division]
GO:0046602 [regulation of mitotic centrosome separation]
GO:0048096 [chromatin-mediated maintenance of transcription]
GO:0071260 [cellular response to mechanical stimulus]
GO:0090399 [replicative senescence]
GO:2000615 [regulation of histone H3-K9 acetylation]
Show all
 442 aa
50.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.