Expression of THYN1 in cancer - Summary - The Human Protein Atlas

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THYN1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	THYN1
Gene description	Thymocyte nuclear protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA038732 , HPA038733
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable).
Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038732	HPA038733

GENE INFORMATION
Gene name	THYN1 (HGNC Symbol)
Synonyms	THY28
Description	Thymocyte nuclear protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q25
Chromosome location (bp)	134248279 - 134253370
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151500 (version 83.38)
Entrez gene	29087
UniProt	Q9P016 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P016
Antibodypedia	THYN1 antibodies

PROTEIN BROWSER

THYN1-001	THYN1-002	THYN1-004	THYN1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
THYN1-001 ENSP00000341452 ENST00000352327	Q9P016 [Direct mapping] Thymocyte nuclear protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] Show all	166 aa 18.8 kDa	No	0
THYN1-002 ENSP00000341657 ENST00000341541	Q9P016 [Direct mapping] Thymocyte nuclear protein 1 A0A024R3M1 [Target identity:100%; Query identity:100%] Thymocyte nuclear protein 1, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] Show all	225 aa 25.7 kDa	No	0
THYN1-004 ENSP00000376373 ENST00000392594	Q9P016 [Direct mapping] Thymocyte nuclear protein 1 A0A024R3M1 [Target identity:100%; Query identity:100%] Thymocyte nuclear protein 1, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] Show all	225 aa 25.7 kDa	No	0
THYN1-005 ENSP00000376374 ENST00000392595	Q9P016 [Direct mapping] Thymocyte nuclear protein 1 A0A024R3M1 [Target identity:100%; Query identity:100%] Thymocyte nuclear protein 1, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] Show all	225 aa 25.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.