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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ADAM17
  • TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADAM17

Gene description

ADAM metallopeptidase domain 17

Protein class

CD markers
Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA010738 , CAB025906
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PROGNOSTIC SUMMARY

Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA010738
CAB025906

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues displayed weak to moderate cytoplasmic staining, in several cases of e.g. colorectal and gastric cancers combined with strong membranous positivity. Most colorectal cancers along with several carcinoids, ovarian, endometrial and gastric cancers showed strong cytoplasmic staining.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues showed weak to moderate cytoplasmic immunoreactivity.

GENE INFORMATION

Gene name

ADAM17 (HGNC Symbol)

Synonyms

CD156B, cSVP, TACE

Description

ADAM metallopeptidase domain 17 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p25.1

Chromosome location (bp)

9488486 - 9555792

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151694 (version 83.38)

Entrez gene

6868

UniProt

P78536 (UniProt - Evidence at protein level)

neXtProt

NX_P78536

Antibodypedia

ADAM17 antibodies

PROTEIN BROWSER

ADAM17-001
ADAM17-003
ADAM17-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAM17-001
ENSP00000309968
ENST00000310823
P78536 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 17
B2RNB2 [Target identity:100%; Query identity:100%]
ADAM metallopeptidase domain 17; ADAM metallopeptidase domain 17 (Tumor necrosis factor, alpha, converting enzyme), isoform CRA_b; ADAM metallopeptidase domain 18
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002446 [neutrophil mediated immunity]
GO:0002467 [germinal center formation]
GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0004222 [metalloendopeptidase activity]
GO:0005112 [Notch binding]
GO:0005138 [interleukin-6 receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006508 [proteolysis]
GO:0006509 [membrane protein ectodomain proteolysis]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0007220 [Notch receptor processing]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0009986 [cell surface]
GO:0010820 [positive regulation of T cell chemotaxis]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0017124 [SH3 domain binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030165 [PDZ domain binding]
GO:0030183 [B cell differentiation]
GO:0030198 [extracellular matrix organization]
GO:0030307 [positive regulation of cell growth]
GO:0030335 [positive regulation of cell migration]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030574 [collagen catabolic process]
GO:0031293 [membrane protein intracellular domain proteolysis]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0032496 [response to lipopolysaccharide]
GO:0032587 [ruffle membrane]
GO:0032722 [positive regulation of chemokine production]
GO:0033025 [regulation of mast cell apoptotic process]
GO:0033077 [T cell differentiation in thymus]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0033627 [cell adhesion mediated by integrin]
GO:0035313 [wound healing, spreading of epidermal cells]
GO:0035625 [epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway]
GO:0042493 [response to drug]
GO:0045121 [membrane raft]
GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048536 [spleen development]
GO:0048870 [cell motility]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051088 [PMA-inducible membrane protein ectodomain proteolysis]
GO:0051272 [positive regulation of cellular component movement]
GO:0055099 [response to high density lipoprotein particle]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
Show all
824 aa
93 kDa
Yes 1
ADAM17-003
ENSP00000418728
ENST00000497134
E7EUI5 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 17
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
Show all
285 aa
33.2 kDa
Yes 0
ADAM17-201
ENSP00000480552
ENST00000618923
A6H8L4 [Direct mapping]
ADAM17 protein; Disintegrin and metalloproteinase domain-containing protein 17
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
Show all
258 aa
30 kDa
Yes 0

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