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Cancer cells showed moderate to strong nuclear immunoreactivity.
GENE INFORMATION
Gene name
XRCC4
Synonyms
Description
X-ray repair complementing defective repair in Chinese hamster cells 4 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq, Sep 2008]
Q13426 [Direct mapping] DNA repair protein XRCC4 A0A024RAQ8 [Target identity:100%; Query identity:100%] X-ray repair complementing defective repair in Chinese hamster cells 4, isoform CRA_b
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Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q13426 [Direct mapping] DNA repair protein XRCC4 A0A024RAL0 [Target identity:100%; Query identity:100%] X-ray repair complementing defective repair in Chinese hamster cells 4, isoform CRA_c
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Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)