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XRCC4

GENERAL INFORMATION

Gene name

 XRCC4

Gene description

 X-ray repair complementing defective repair in Chinese hamster cells 4

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA006801
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable).
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006801

GENE INFORMATION

Gene name

 XRCC4

Synonyms

Description

 X-ray repair complementing defective repair in Chinese hamster cells 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq, Sep 2008]

Chromosome

 5

Cytoband

 q14.2

Chromosome location (bp)

 83077498 - 83353787

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152422 (version 83.38)

Entrez gene

 7518

UniProt

 Q13426 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13426

Antibodypedia

 XRCC4 antibodies

PROTEIN BROWSER
XRCC4-001
XRCC4-002
XRCC4-003
XRCC4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
XRCC4-001
ENSP00000379344
ENST00000396027
Q13426 [Direct mapping]
DNA repair protein XRCC4
A0A024RAL0 [Target identity:100%; Query identity:100%]
X-ray repair complementing defective repair in Chinese hamster cells 4, isoform CRA_c
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005958 [DNA-dependent protein kinase-DNA ligase 4 complex]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0008022 [protein C-terminus binding]
GO:0010165 [response to X-ray]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0030054 [cell junction]
GO:0032807 [DNA ligase IV complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0051351 [positive regulation of ligase activity]
GO:0070419 [nonhomologous end joining complex]
GO:0075713 [establishment of integrated proviral latency]
Show all
 334 aa
38.1 kDa 		No 0
XRCC4-002
ENSP00000342011
ENST00000338635
Q13426 [Direct mapping]
DNA repair protein XRCC4
A0A024RAQ8 [Target identity:100%; Query identity:100%]
X-ray repair complementing defective repair in Chinese hamster cells 4, isoform CRA_b
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005958 [DNA-dependent protein kinase-DNA ligase 4 complex]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0008022 [protein C-terminus binding]
GO:0010165 [response to X-ray]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0030054 [cell junction]
GO:0032807 [DNA ligase IV complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0051351 [positive regulation of ligase activity]
GO:0070419 [nonhomologous end joining complex]
GO:0075713 [establishment of integrated proviral latency]
Show all
 336 aa
38.3 kDa 		No 0
XRCC4-003
ENSP00000421491
ENST00000511817
Q13426 [Direct mapping]
DNA repair protein XRCC4
A0A024RAQ8 [Target identity:100%; Query identity:100%]
X-ray repair complementing defective repair in Chinese hamster cells 4, isoform CRA_b
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005958 [DNA-dependent protein kinase-DNA ligase 4 complex]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0008022 [protein C-terminus binding]
GO:0010165 [response to X-ray]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0030054 [cell junction]
GO:0032807 [DNA ligase IV complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0051351 [positive regulation of ligase activity]
GO:0070419 [nonhomologous end joining complex]
GO:0071285 [cellular response to lithium ion]
GO:0075713 [establishment of integrated proviral latency]
Show all
 336 aa
38.3 kDa 		No 0
XRCC4-201
ENSP00000282268
ENST00000282268
Q13426 [Direct mapping]
DNA repair protein XRCC4
A0A024RAL0 [Target identity:100%; Query identity:100%]
X-ray repair complementing defective repair in Chinese hamster cells 4, isoform CRA_c
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005958 [DNA-dependent protein kinase-DNA ligase 4 complex]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0008022 [protein C-terminus binding]
GO:0010165 [response to X-ray]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0030054 [cell junction]
GO:0032807 [DNA ligase IV complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0051351 [positive regulation of ligase activity]
GO:0070419 [nonhomologous end joining complex]
GO:0075713 [establishment of integrated proviral latency]
Show all
 334 aa
38.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.