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XRCC4

GENERAL INFORMATION

Gene name

 XRCC4

Gene description

 X-ray repair complementing defective repair in Chinese hamster cells 4

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA006801
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 XRCC4

Synonyms

Description

 X-ray repair complementing defective repair in Chinese hamster cells 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq, Sep 2008]

Chromosome

 5

Cytoband

 q14.2

Chromosome location (bp)

 83077498 - 83353787

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152422 (version 83.38)

Entrez gene

 7518

UniProt

 Q13426 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13426

Antibodypedia

 XRCC4 antibodies

PROTEIN BROWSER
XRCC4-001
XRCC4-002
XRCC4-003
XRCC4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
XRCC4-001
ENSP00000379344
ENST00000396027
Q13426 [Direct mapping]
DNA repair protein XRCC4
A0A024RAL0 [Target identity:100%; Query identity:100%]
X-ray repair complementing defective repair in Chinese hamster cells 4, isoform CRA_c
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005958 [DNA-dependent protein kinase-DNA ligase 4 complex]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0008022 [protein C-terminus binding]
GO:0010165 [response to X-ray]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0030054 [cell junction]
GO:0032807 [DNA ligase IV complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0051351 [positive regulation of ligase activity]
GO:0070419 [nonhomologous end joining complex]
GO:0075713 [establishment of integrated proviral latency]
Show all
 334 aa
38.1 kDa 		No 0
XRCC4-002
ENSP00000342011
ENST00000338635
Q13426 [Direct mapping]
DNA repair protein XRCC4
A0A024RAQ8 [Target identity:100%; Query identity:100%]
X-ray repair complementing defective repair in Chinese hamster cells 4, isoform CRA_b
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005958 [DNA-dependent protein kinase-DNA ligase 4 complex]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0008022 [protein C-terminus binding]
GO:0010165 [response to X-ray]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0030054 [cell junction]
GO:0032807 [DNA ligase IV complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0051351 [positive regulation of ligase activity]
GO:0070419 [nonhomologous end joining complex]
GO:0075713 [establishment of integrated proviral latency]
Show all
 336 aa
38.3 kDa 		No 0
XRCC4-003
ENSP00000421491
ENST00000511817
Q13426 [Direct mapping]
DNA repair protein XRCC4
A0A024RAQ8 [Target identity:100%; Query identity:100%]
X-ray repair complementing defective repair in Chinese hamster cells 4, isoform CRA_b
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005958 [DNA-dependent protein kinase-DNA ligase 4 complex]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0008022 [protein C-terminus binding]
GO:0010165 [response to X-ray]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0030054 [cell junction]
GO:0032807 [DNA ligase IV complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0051351 [positive regulation of ligase activity]
GO:0070419 [nonhomologous end joining complex]
GO:0071285 [cellular response to lithium ion]
GO:0075713 [establishment of integrated proviral latency]
Show all
 336 aa
38.3 kDa 		No 0
XRCC4-201
ENSP00000282268
ENST00000282268
Q13426 [Direct mapping]
DNA repair protein XRCC4
A0A024RAL0 [Target identity:100%; Query identity:100%]
X-ray repair complementing defective repair in Chinese hamster cells 4, isoform CRA_c
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005958 [DNA-dependent protein kinase-DNA ligase 4 complex]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0008022 [protein C-terminus binding]
GO:0010165 [response to X-ray]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0030054 [cell junction]
GO:0032807 [DNA ligase IV complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0051351 [positive regulation of ligase activity]
GO:0070419 [nonhomologous end joining complex]
GO:0075713 [establishment of integrated proviral latency]
Show all
 334 aa
38.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.