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CAMK4

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GENERAL INFORMATION

Gene name

 CAMK4

Gene description

 Calcium/calmodulin-dependent protein kinase IV

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoli (fibrillar center) & nucleoplasm.

RNA cell category

 Cell line enhanced (HDLM-2, SH-SY5Y)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Nucleoli fibrillar center (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA011753
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2, SH-SY5Y)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoli (fibrillar center) & nucleoplasm.

Main location

 Nucleoplasm (supported), Nucleoli fibrillar center (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA011753 A-431 Nucleoplasm
Nucleoli fibrillar center
HPA011753 U-2 OS Nucleoplasm
Nucleoli fibrillar center
HPA011753 U-251 MG Nucleoplasm
Nucleoli fibrillar center

GENE INFORMATION

Gene name

 CAMK4 (HGNC Symbol)

Synonyms

 CaMK-GR

Description

 Calcium/calmodulin-dependent protein kinase IV (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q22.1

Chromosome location (bp)

 111223653 - 111494886

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152495 (version 83.38)

Entrez gene

 814

UniProt

 Q16566 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16566

Antibodypedia

 CAMK4 antibodies

PROTEIN BROWSER
CAMK4-001
CAMK4-004
CAMK4-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CAMK4-001
ENSP00000282356
ENST00000282356
Q16566 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type IV
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006913 [nucleocytoplasmic transport]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0007270 [neuron-neuron synaptic transmission]
GO:0007616 [long-term memory]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0033081 [regulation of T cell differentiation in thymus]
GO:0035556 [intracellular signal transduction]
GO:0043011 [myeloid dendritic cell differentiation]
GO:0045087 [innate immune response]
GO:0045670 [regulation of osteoclast differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046777 [protein autophosphorylation]
GO:0046827 [positive regulation of protein export from nucleus]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 473 aa
51.9 kDa 		No 1
CAMK4-004
ENSP00000422634
ENST00000512453
Q16566 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type IV
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0007616 [long-term memory]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0033081 [regulation of T cell differentiation in thymus]
GO:0035556 [intracellular signal transduction]
GO:0043011 [myeloid dendritic cell differentiation]
GO:0045087 [innate immune response]
GO:0045670 [regulation of osteoclast differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046777 [protein autophosphorylation]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 473 aa
51.9 kDa 		No 1
CAMK4-005
ENSP00000426940
ENST00000508074
D6RE65 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type IV
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0046777 [protein autophosphorylation]
Show all
 142 aa
15.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.