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CAMK4

GENERAL INFORMATION

Gene name

 CAMK4

Gene description

 Calcium/calmodulin-dependent protein kinase IV

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, testis)
GTEx:Tissue enhanced (cerebellum)
FANTOM5:Group enriched (caudate, cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic staining at variable levels in several tissues, most abundant in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA011753 , HPA017206 , CAB004347
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebellum)

GENE INFORMATION

Gene name

 CAMK4 (HGNC Symbol)

Synonyms

 CaMK-GR

Description

 Calcium/calmodulin-dependent protein kinase IV (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q22.1

Chromosome location (bp)

 111223653 - 111494886

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152495 (version 83.38)

Entrez gene

 814

UniProt

 Q16566 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16566

Antibodypedia

 CAMK4 antibodies

PROTEIN BROWSER
CAMK4-001
CAMK4-004
CAMK4-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CAMK4-001
ENSP00000282356
ENST00000282356
Q16566 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type IV
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006913 [nucleocytoplasmic transport]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0007270 [neuron-neuron synaptic transmission]
GO:0007616 [long-term memory]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0033081 [regulation of T cell differentiation in thymus]
GO:0035556 [intracellular signal transduction]
GO:0043011 [myeloid dendritic cell differentiation]
GO:0045087 [innate immune response]
GO:0045670 [regulation of osteoclast differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046777 [protein autophosphorylation]
GO:0046827 [positive regulation of protein export from nucleus]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 473 aa
51.9 kDa 		No 1
CAMK4-004
ENSP00000422634
ENST00000512453
Q16566 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type IV
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0007616 [long-term memory]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0033081 [regulation of T cell differentiation in thymus]
GO:0035556 [intracellular signal transduction]
GO:0043011 [myeloid dendritic cell differentiation]
GO:0045087 [innate immune response]
GO:0045670 [regulation of osteoclast differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046777 [protein autophosphorylation]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 473 aa
51.9 kDa 		No 1
CAMK4-005
ENSP00000426940
ENST00000508074
D6RE65 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type IV
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0046777 [protein autophosphorylation]
Show all
 142 aa
15.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.