Tissue expression of CAST - Summary - The Human Protein Atlas

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CAST

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CAST
Gene description	Calpastatin
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	28
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 3 antibodies. HPA036881 , HPA036882 , CAB009491
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

Skeletal muscle

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	CAST
Synonyms
Description	Calpastatin (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
Chromosome	5
Cytoband	q15
Chromosome location (bp)	96525267 - 96779595
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153113 (version 83.38)
Entrez gene	831
UniProt	P20810 (UniProt - Evidence at protein level)
neXtProt	NX_P20810
Antibodypedia	CAST antibodies

PROTEIN BROWSER

CAST-003	CAST-004	CAST-005	CAST-006	CAST-007	CAST-008	CAST-009	CAST-010	CAST-011	CAST-012	CAST-013	CAST-014	CAST-015	CAST-016	CAST-017	CAST-018	CAST-020	CAST-023	CAST-025	CAST-026	CAST-032	CAST-033	CAST-037	CAST-038	CAST-039	CAST-041	CAST-201	CAST-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CAST-003 ENSP00000312523 ENST00000309190	P20810 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0044822 [poly(A) RNA binding] GO:2000675 [negative regulation of type B pancreatic cell apoptotic process] Show all	686 aa 74.1 kDa	No	0
CAST-004 ENSP00000339914 ENST00000341926	P20810 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0044822 [poly(A) RNA binding] GO:2000675 [negative regulation of type B pancreatic cell apoptotic process] Show all	708 aa 76.6 kDa	No	0
CAST-005 ENSP00000343421 ENST00000338252	P20810 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0044822 [poly(A) RNA binding] GO:2000675 [negative regulation of type B pancreatic cell apoptotic process] Show all	695 aa 75.3 kDa	No	0
CAST-006 ENSP00000422957 ENST00000505143	H0Y944 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		288 aa 30.6 kDa	No	0
CAST-007 ENSP00000422951 ENST00000511097	F8W7E0 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	393 aa 41.7 kDa	No	0
CAST-008 ENSP00000425721 ENST00000508830	P20810 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0044822 [poly(A) RNA binding] GO:2000675 [negative regulation of type B pancreatic cell apoptotic process] Show all	791 aa 84.9 kDa	No	0
CAST-009 ENSP00000396558 ENST00000421689	E9PSG1 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		304 aa 31.9 kDa	No	0
CAST-010 ENSP00000422176 ENST00000510756	P20810 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0044822 [poly(A) RNA binding] GO:2000675 [negative regulation of type B pancreatic cell apoptotic process] Show all	769 aa 82.4 kDa	No	0
CAST-011 ENSP00000379157 ENST00000395812	P20810 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001889 [liver development] GO:0002020 [protease binding] GO:0004866 [endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007343 [egg activation] GO:0007420 [brain development] GO:0007520 [myoblast fusion] GO:0007568 [aging] GO:0010466 [negative regulation of peptidase activity] GO:0010859 [calcium-dependent cysteine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0031100 [organ regeneration] GO:0043086 [negative regulation of catalytic activity] GO:0044822 [poly(A) RNA binding] GO:0045445 [myoblast differentiation] GO:0071157 [negative regulation of cell cycle arrest] GO:2000675 [negative regulation of type B pancreatic cell apoptotic process] Show all	750 aa 80.3 kDa	No	0
CAST-012 ENSP00000422677 ENST00000508608	A0A0C4DGB5 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		754 aa 81 kDa	No	0
CAST-013 ENSP00000421130 ENST00000511049	E7EVY3 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	693 aa 74.9 kDa	No	0
CAST-014 ENSP00000424160 ENST00000510500	H0Y9H6 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		465 aa 50.5 kDa	No	0
CAST-015 ENSP00000422929 ENST00000515663	E7EQA0 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		431 aa 47.2 kDa	No	0
CAST-016 ENSP00000422325 ENST00000510156	E7ES10 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	642 aa 69.7 kDa	No	0
CAST-017 ENSP00000426946 ENST00000509903	E9PCH5 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	673 aa 72.8 kDa	No	0
CAST-018 ENSP00000423638 ENST00000511782	B7Z574 [Direct mapping] Calpastatin; cDNA FLJ56123, highly similar to Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	694 aa 75 kDa	No	0
CAST-020 ENSP00000425670 ENST00000504465	E9PDE4 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	636 aa 69 kDa	No	0
CAST-023 ENSP00000422612 ENST00000514845	D6RBR1 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		150 aa 15.5 kDa	No	0
CAST-025 ENSP00000427092 ENST00000506811	E7EN75 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		156 aa 16.7 kDa	No	0
CAST-026 ENSP00000421230 ENST00000514055	D6RGF7 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		149 aa 15.8 kDa	No	0
CAST-032 ENSP00000426422 ENST00000512620	H0YA91 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		301 aa 31.7 kDa	No	0
CAST-033 ENSP00000422831 ENST00000508197	E7EQK6 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		156 aa 17 kDa	No	0
CAST-037 ENSP00000425787 ENST00000508579	E7EQ12 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		423 aa 46.1 kDa	No	0
CAST-038 ENSP00000422807 ENST00000503828	D6RAA8 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		78 aa 8.7 kDa	No	0
CAST-039 ENSP00000423846 ENST00000509259	D6RC54 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		91 aa 10 kDa	No	0
CAST-041 ENSP00000412374 ENST00000437034	H0Y7F0 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		436 aa 47.7 kDa	No	0
CAST-201 ENSP00000320319 ENST00000325674	A0A0A0MR45 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		430 aa 47 kDa	No	0
CAST-202 ENSP00000379158 ENST00000395813	P20810 [Direct mapping] Calpastatin Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0044822 [poly(A) RNA binding] GO:2000675 [negative regulation of type B pancreatic cell apoptotic process] Show all	708 aa 76.6 kDa	No	0

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