Expression of CLGN in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CLGN
Gene description	Calmegin
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (prostate cancer)
HPA (cell line):	Cell line enhanced (U-251 MG)
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in seminiferous ducts of testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA048761 , HPA058627 , CAB020709
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (prostate cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA048761	HPA058627	CAB020709

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Most cancer tissues showed weak to moderate cytoplasmic immunoreactivity often with a granular pattern.

GENE INFORMATION
Gene name	CLGN
Synonyms
Description	Calmegin (HGNC Symbol)
Entrez gene summary	Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q31.1
Chromosome location (bp)	140388455 - 140427968
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153132 (version 83.38)
Entrez gene	1047
UniProt	O14967 (UniProt - Evidence at protein level)
neXtProt	NX_O14967
Antibodypedia	CLGN antibodies

PROTEIN BROWSER

CLGN-001	CLGN-004	CLGN-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLGN-001 ENSP00000326699 ENST00000325617	O14967 [Direct mapping] Calmegin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006461 [protein complex assembly] GO:0007338 [single fertilization] GO:0007339 [binding of sperm to zona pellucida] GO:0016021 [integral component of membrane] GO:0044183 [protein binding involved in protein folding] GO:0051082 [unfolded protein binding] Show all	610 aa 70 kDa	Yes	1
CLGN-004 ENSP00000424593 ENST00000509477	D6RAZ4 [Direct mapping] Calmegin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	179 aa 20.5 kDa	Yes	0
CLGN-201 ENSP00000392782 ENST00000414773	O14967 [Direct mapping] Calmegin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0007338 [single fertilization] GO:0016021 [integral component of membrane] GO:0051082 [unfolded protein binding] Show all	610 aa 70 kDa	Yes	1