Tissue expression of CLGN - Summary - The Human Protein Atlas

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CLGN

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TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CLGN
Gene description	Calmegin
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (testis)
GTEx:	Tissue enhanced (testis)
FANTOM5:	Group enriched (heart muscle, pituitary gland, testis)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues, most abundant in seminiferous ducts of testis.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA048761 , HPA058627 , CAB020709
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (heart muscle, pituitary gland, testis)

GENE INFORMATION
Gene name	CLGN
Synonyms
Description	Calmegin (HGNC Symbol)
Entrez gene summary	Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q31.1
Chromosome location (bp)	140388455 - 140427968
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153132 (version 83.38)
Entrez gene	1047
UniProt	O14967 (UniProt - Evidence at protein level)
neXtProt	NX_O14967
Antibodypedia	CLGN antibodies

PROTEIN BROWSER

CLGN-001	CLGN-004	CLGN-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLGN-001 ENSP00000326699 ENST00000325617	O14967 [Direct mapping] Calmegin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006461 [protein complex assembly] GO:0007338 [single fertilization] GO:0007339 [binding of sperm to zona pellucida] GO:0016021 [integral component of membrane] GO:0044183 [protein binding involved in protein folding] GO:0051082 [unfolded protein binding] Show all	610 aa 70 kDa	Yes	1
CLGN-004 ENSP00000424593 ENST00000509477	D6RAZ4 [Direct mapping] Calmegin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	179 aa 20.5 kDa	Yes	0
CLGN-201 ENSP00000392782 ENST00000414773	O14967 [Direct mapping] Calmegin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0007338 [single fertilization] GO:0016021 [integral component of membrane] GO:0051082 [unfolded protein binding] Show all	610 aa 70 kDa	Yes	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.