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CD8A

GENERAL INFORMATION

Gene name

 CD8A

Gene description

 CD8a molecule

Protein class

 CD markers
Disease related genes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enriched (MOLT-4)
HPA (normal tissue):Tissue enhanced (spleen)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in subsets of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 3 antibodies.
HPA037756 , CAB000012 , CAB075722
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), renal cancer (unfavourable) and cervical cancer (favourable).
Endometrial cancer p<0.001
Renal cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA037756
CAB000012
CAB075722

GENE INFORMATION

Gene name

 CD8A (HGNC Symbol)

Synonyms

 CD8

Description

 CD8a molecule (HGNC Symbol)

Entrez gene summary

 The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Chromosome

 2

Cytoband

 p11.2

Chromosome location (bp)

 86784610 - 86808396

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000153563 (version 83.38)

Entrez gene

 925

UniProt

 P01732 (UniProt - Evidence at protein level)

neXtProt

 NX_P01732

Antibodypedia

 CD8A antibodies

PROTEIN BROWSER
CD8A-001
CD8A-002
CD8A-004
CD8A-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD8A-001
ENSP00000283635
ENST00000283635
P01732 [Direct mapping]
T-cell surface glycoprotein CD8 alpha chain
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002456 [T cell mediated immunity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0009897 [external side of plasma membrane]
GO:0015026 [coreceptor activity]
GO:0019882 [antigen processing and presentation]
GO:0042101 [T cell receptor complex]
GO:0042110 [T cell activation]
GO:0042288 [MHC class I protein binding]
GO:0045065 [cytotoxic T cell differentiation]
GO:0050776 [regulation of immune response]
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 235 aa
25.7 kDa 		Yes 1
CD8A-002
ENSP00000321631
ENST00000352580
P01732 [Direct mapping]
T-cell surface glycoprotein CD8 alpha chain
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CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002456 [T cell mediated immunity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0009897 [external side of plasma membrane]
GO:0015026 [coreceptor activity]
GO:0019882 [antigen processing and presentation]
GO:0042101 [T cell receptor complex]
GO:0042110 [T cell activation]
GO:0042288 [MHC class I protein binding]
GO:0045065 [cytotoxic T cell differentiation]
GO:0050776 [regulation of immune response]
Show all
 198 aa
21.6 kDa 		Yes 0
CD8A-004
ENSP00000387314
ENST00000409781
B8ZZZ4 [Direct mapping]
CD8 antigen, alpha polypeptide (P32), isoform CRA_c; T-cell surface glycoprotein CD8 alpha chain
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
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 198 aa
22.1 kDa 		Yes 1
CD8A-006
ENSP00000386559
ENST00000409511
P01732 [Direct mapping]
T-cell surface glycoprotein CD8 alpha chain
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002456 [T cell mediated immunity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0019882 [antigen processing and presentation]
GO:0019901 [protein kinase binding]
GO:0042101 [T cell receptor complex]
GO:0042110 [T cell activation]
GO:0042288 [MHC class I protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045065 [cytotoxic T cell differentiation]
GO:0050776 [regulation of immune response]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0051607 [defense response to virus]
Show all
 235 aa
25.7 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.