Cell atlas - SREK1 - The Human Protein Atlas

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SREK1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SREK1
Gene description	Splicing regulatory glutamine/lysine-rich protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated), Nuclear speckles (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA037673 , HPA059332
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles & nucleoplasm.

Main location

Nucleoplasm (validated), Nuclear speckles (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA037673	HeLa	Nucleoplasm
HPA037673	HeLa	Nuclear speckles
HPA037673	U-2 OS	Nucleoplasm
HPA037673	U-2 OS	Nuclear speckles
HPA059332	HeLa	Nucleoplasm
HPA059332	HeLa	Nuclear speckles
HPA059332	U-2 OS	Nucleoplasm
HPA059332	U-251 MG	Nucleoplasm
HPA059332	U-251 MG	Nuclear speckles

GENE INFORMATION
Gene name	SREK1 (HGNC Symbol)
Synonyms	DKFZp564B176, SFRS12, SRrp508, SRrp86
Description	Splicing regulatory glutamine/lysine-rich protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif (RRM) domains. The encoded protein interacts with other SR proteins to modulate splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Chromosome	5
Cytoband	q12.3
Chromosome location (bp)	66139971 - 66183615
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153914 (version 83.38)
Entrez gene	140890
UniProt	Q8WXA9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WXA9
Antibodypedia	SREK1 antibodies

PROTEIN BROWSER

SREK1-001	SREK1-002	SREK1-003	SREK1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SREK1-001 ENSP00000334538 ENST00000334121	Q8WXA9 [Direct mapping] Splicing regulatory glutamine/lysine-rich protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005681 [spliceosomal complex] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0044822 [poly(A) RNA binding] Show all	624 aa 71.6 kDa	No	0
SREK1-002 ENSP00000370305 ENST00000380918	Q8WXA9 [Direct mapping] Splicing regulatory glutamine/lysine-rich protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005681 [spliceosomal complex] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0044822 [poly(A) RNA binding] Show all	508 aa 59.4 kDa	No	0
SREK1-003 ENSP00000428272 ENST00000521691	E5RJ76 [Direct mapping] Splicing regulatory glutamine/lysine-rich protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		76 aa 7.8 kDa	No	0
SREK1-201 ENSP00000481430 ENST00000612404	A0A087WY03 [Direct mapping] Splicing regulatory glutamine/lysine-rich protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	100 aa 10.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.