Fields »
ABOUT
HELP
BLOG
SREK1

GENERAL INFORMATION

Gene name

 SREK1

Gene description

 Splicing regulatory glutamine/lysine-rich protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA037674
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable) and renal cancer (unfavourable).
Head and neck cancer p<0.001
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037674

GENE INFORMATION

Gene name

 SREK1 (HGNC Symbol)

Synonyms

 DKFZp564B176, SFRS12, SRrp508, SRrp86

Description

 Splicing regulatory glutamine/lysine-rich protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif (RRM) domains. The encoded protein interacts with other SR proteins to modulate splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Chromosome

 5

Cytoband

 q12.3

Chromosome location (bp)

 66139971 - 66183615

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000153914 (version 83.38)

Entrez gene

 140890

UniProt

 Q8WXA9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WXA9

Antibodypedia

 SREK1 antibodies

PROTEIN BROWSER
SREK1-001
SREK1-002
SREK1-003
SREK1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SREK1-001
ENSP00000334538
ENST00000334121
Q8WXA9 [Direct mapping]
Splicing regulatory glutamine/lysine-rich protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0044822 [poly(A) RNA binding]
Show all
 624 aa
71.6 kDa 		No 0
SREK1-002
ENSP00000370305
ENST00000380918
Q8WXA9 [Direct mapping]
Splicing regulatory glutamine/lysine-rich protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0044822 [poly(A) RNA binding]
Show all
 508 aa
59.4 kDa 		No 0
SREK1-003
ENSP00000428272
ENST00000521691
E5RJ76 [Direct mapping]
Splicing regulatory glutamine/lysine-rich protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 76 aa
7.8 kDa 		No 0
SREK1-201
ENSP00000481430
ENST00000612404
A0A087WY03 [Direct mapping]
Splicing regulatory glutamine/lysine-rich protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 100 aa
10.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.