Expression of CHODL in cancer - Summary - The Human Protein Atlas

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CHODL

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CHODL
Gene description	Chondrolectin
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (U-266/84, U-87 MG)
HPA (normal tissue):	Tissue enhanced (spleen, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous positivity mainly in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA017282
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA017282

GENE INFORMATION
Gene name	CHODL (HGNC Symbol)
Synonyms	C21orf68, FLJ12627, MT75, PRED12
Description	Chondrolectin (HGNC Symbol)
Entrez gene summary	This gene encodes a type I membrane protein with a carbohydrate recognition domain characteristic of C-type lectins in its extracellular portion. In other proteins, this domain is involved in endocytosis of glycoproteins and exogenous sugar-bearing pathogens. This protein localizes predominantly to the perinuclear region. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Chromosome	21
Cytoband	q21.1
Chromosome location (bp)	17901263 - 18267373
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154645 (version 83.38)
Entrez gene	140578
UniProt	Q9H9P2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H9P2
Antibodypedia	CHODL antibodies

PROTEIN BROWSER

CHODL-001	CHODL-002	CHODL-003	CHODL-004	CHODL-005	CHODL-009	CHODL-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHODL-001 ENSP00000299295 ENST00000299295	Q9H9P2 [Direct mapping] Chondrolectin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005737 [cytoplasm] GO:0007517 [muscle organ development] GO:0010975 [regulation of neuron projection development] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0048471 [perinuclear region of cytoplasm] Show all	273 aa 30.4 kDa	Yes	1
CHODL-002 ENSP00000382993 ENST00000400128	Q9H9P2 [Direct mapping] Chondrolectin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005737 [cytoplasm] GO:0007517 [muscle organ development] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0048471 [perinuclear region of cytoplasm] Show all	232 aa 26 kDa	No	1
CHODL-003 ENSP00000382996 ENST00000400131	A0A0C4DFS2 [Direct mapping] Chondrolectin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all		236 aa 27.2 kDa	No	0
CHODL-004 ENSP00000383001 ENST00000400135	A0A0C4DFS2 [Direct mapping] Chondrolectin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all		236 aa 27.2 kDa	No	0
CHODL-005 ENSP00000382992 ENST00000400127	Q9H9P2 [Direct mapping] Chondrolectin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005737 [cytoplasm] GO:0007517 [muscle organ development] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0048471 [perinuclear region of cytoplasm] Show all	232 aa 26 kDa	No	1
CHODL-009 ENSP00000443566 ENST00000543733	Q9H9P2 [Direct mapping] Chondrolectin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005737 [cytoplasm] GO:0007517 [muscle organ development] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0048471 [perinuclear region of cytoplasm] Show all	254 aa 28.4 kDa	No	1
CHODL-201 ENSP00000339975 ENST00000338326	A0A0C4DFS2 [Direct mapping] Chondrolectin Show all	Predicted intracellular proteins Show all		236 aa 27.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.