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ADAMTS5

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GENERAL INFORMATION

Gene name

 ADAMTS5

Gene description

 ADAM metallopeptidase with thrombospondin type 1 motif, 5

Protein class

 Cancer-related genes
Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm.

RNA cell category

 Group enriched (RH-30, U-87 MG, ASC TERT1, U-138 MG, LHCN-M2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA030906 , HPA030908
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (RH-30, U-87 MG, ASC TERT1, U-138 MG, LHCN-M2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm.

Main location

 Nucleoplasm (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA030906 HEK 293 Nucleoplasm
Mitochondria
HPA030906 RH-30 Nucleoplasm
HPA030906 U-2 OS Nucleoplasm
HPA030908 RH-30 Nucleoplasm

GENE INFORMATION

Gene name

 ADAMTS5 (HGNC Symbol)

Synonyms

 ADAMTS11, ADMP-2

Description

 ADAM metallopeptidase with thrombospondin type 1 motif, 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q21.3

Chromosome location (bp)

 26917912 - 26966513

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154736 (version 83.38)

Entrez gene

 11096

UniProt

 Q9UNA0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UNA0

Antibodypedia

 ADAMTS5 antibodies

PROTEIN BROWSER
ADAMTS5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADAMTS5-001
ENSP00000284987
ENST00000284987
Q9UNA0 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 5
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Enzymes
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006493 [protein O-linked glycosylation]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0036066 [protein O-linked fucosylation]
GO:0042742 [defense response to bacterium]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
Show all
 930 aa
101.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.