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ADAMTS5

GENERAL INFORMATION

Gene name

 ADAMTS5

Gene description

 ADAM metallopeptidase with thrombospondin type 1 motif, 5

Protein class

 Cancer-related genes
Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (ASC TERT1, LHCN-M2, RH-30, U-138 MG, U-87 MG)
HPA (normal tissue):Tissue enhanced (placenta)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression at variable levels in several different cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 2 antibodies.
HPA005661 , CAB025996
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and thyroid cancer (unfavourable).
Renal cancer p<0.001
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA005661
CAB025996

GENE INFORMATION

Gene name

 ADAMTS5 (HGNC Symbol)

Synonyms

 ADAMTS11, ADMP-2

Description

 ADAM metallopeptidase with thrombospondin type 1 motif, 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q21.3

Chromosome location (bp)

 26917912 - 26966513

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154736 (version 83.38)

Entrez gene

 11096

UniProt

 Q9UNA0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UNA0

Antibodypedia

 ADAMTS5 antibodies

PROTEIN BROWSER
ADAMTS5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADAMTS5-001
ENSP00000284987
ENST00000284987
Q9UNA0 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 5
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Enzymes
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
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GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006493 [protein O-linked glycosylation]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0036066 [protein O-linked fucosylation]
GO:0042742 [defense response to bacterium]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
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 930 aa
101.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.