A few cases of colorectal cancers displayed strong cytoplasmic immunoreactivity while several malignant melanomas displayed moderate staining. Remaining malignant cells were generally negative or weakly stained.
ADAMTS5 (HGNC Symbol)
ADAM metallopeptidase with thrombospondin type 1 motif, 5 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq, Jul 2008]