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Group enriched (ASC TERT1, LHCN-M2, RH-30, U-138 MG, U-87 MG)
HPA (normal tissue):
Tissue enhanced (placenta)
Protein evidence
Evidence at protein level
Protein expression normal tissue
Cytoplasmic expression at variable levels in several different cell types.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
A few cases of colorectal cancers displayed strong cytoplasmic immunoreactivity while several malignant melanomas displayed moderate staining. Remaining malignant cells were generally negative or weakly stained.
GENE INFORMATION
Gene name
ADAMTS5 (HGNC Symbol)
Synonyms
ADAMTS11, ADMP-2
Description
ADAM metallopeptidase with thrombospondin type 1 motif, 5 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq, Jul 2008]