Expression of OTUD6B in cancer - Summary - The Human Protein Atlas

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OTUD6B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	OTUD6B
Gene description	OTU domain containing 6B
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 3 antibodies. HPA024046 , HPA024503 , HPA024772
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA024046	HPA024503	HPA024772

GENE INFORMATION
Gene name	OTUD6B (HGNC Symbol)
Synonyms	CGI-77, DUBA5
Description	OTU domain containing 6B (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes. Deubiquitinating enzymes are primarily involved in removing ubiquitin from proteins targeted for degradation. This protein may function as a negative regulator of the cell cycle in B cells. [provided by RefSeq, Nov 2013]
Chromosome	8
Cytoband	q21.3
Chromosome location (bp)	91070196 - 91087095
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000155100 (version 83.38)
Entrez gene	51633
UniProt	Q8N6M0 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N6M0
Antibodypedia	OTUD6B antibodies

PROTEIN BROWSER

OTUD6B-001	OTUD6B-004	OTUD6B-201	OTUD6B-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OTUD6B-001 ENSP00000285420 ENST00000285420	A0A087X0W9 [Direct mapping] OTU domain containing 6B, isoform CRA_b; OTU domain-containing protein 6B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		323 aa 37.3 kDa	No	0
OTUD6B-004 ENSP00000384190 ENST00000404789	Q8N6M0 [Direct mapping] OTU domain-containing protein 6B Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	293 aa 33.8 kDa	No	0
OTUD6B-201 ENSP00000481196 ENST00000615618	Q8N6M0 [Direct mapping] OTU domain-containing protein 6B Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	192 aa 21.8 kDa	No	0
OTUD6B-202 ENSP00000483706 ENST00000617869	A0A087X0W9 [Direct mapping] OTU domain containing 6B, isoform CRA_b; OTU domain-containing protein 6B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		323 aa 37.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.