Cell atlas - DCK - The Human Protein Atlas

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DCK

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	DCK
Gene description	Deoxycytidine kinase
Protein class	Enzymes FDA approved drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA059609
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA059609	MCF7	Nucleus
	HPA059609	U-2 OS	Nucleus

GENE INFORMATION
Gene name	DCK
Synonyms
Description	Deoxycytidine kinase (HGNC Symbol)
Entrez gene summary	Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	70992538 - 71030914
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156136 (version 83.38)
Entrez gene	1633
UniProt	P27707 (UniProt - Evidence at protein level)
neXtProt	NX_P27707
Antibodypedia	DCK antibodies

PROTEIN BROWSER

DCK-001	DCK-004	DCK-005	DCK-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DCK-001 ENSP00000286648 ENST00000286648	P27707 [Direct mapping] Deoxycytidine kinase F5CTF3 [Target identity:100%; Query identity:100%] Deoxynucleoside kinase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004137 [deoxycytidine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006144 [purine nucleobase metabolic process] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0006220 [pyrimidine nucleotide metabolic process] GO:0008144 [drug binding] GO:0009157 [deoxyribonucleoside monophosphate biosynthetic process] GO:0009165 [nucleotide biosynthetic process] GO:0016310 [phosphorylation] GO:0019206 [nucleoside kinase activity] GO:0042803 [protein homodimerization activity] GO:0043097 [pyrimidine nucleoside salvage] GO:0043101 [purine-containing compound salvage] GO:0044281 [small molecule metabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	260 aa 30.5 kDa	No	0
DCK-004 ENSP00000425578 ENST00000504730	D6RCP9 [Direct mapping] Deoxycytidine kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0006139 [nucleobase-containing compound metabolic process] GO:0009165 [nucleotide biosynthetic process] GO:0019206 [nucleoside kinase activity] Show all	199 aa 22.9 kDa	No	0
DCK-005 ENSP00000421508 ENST00000504952	D6RFG8 [Direct mapping] Deoxycytidine kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	317 aa 36.8 kDa	No	0
DCK-006 ENSP00000422971 ENST00000509617	D6R9C6 [Direct mapping] Deoxycytidine kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		15 aa 1.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.