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DCK

GENERAL INFORMATION

Gene name

 DCK

Gene description

 Deoxycytidine kinase

Protein class

 Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in a subset of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Approved based on 1 antibody.
HPA062773
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA062773

GENE INFORMATION

Gene name

 DCK

Synonyms

Description

 Deoxycytidine kinase (HGNC Symbol)

Entrez gene summary

 Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q13.3

Chromosome location (bp)

 70992538 - 71030914

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156136 (version 83.38)

Entrez gene

 1633

UniProt

 P27707 (UniProt - Evidence at protein level)

neXtProt

 NX_P27707

Antibodypedia

 DCK antibodies

PROTEIN BROWSER
DCK-001
DCK-004
DCK-005
DCK-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DCK-001
ENSP00000286648
ENST00000286648
P27707 [Direct mapping]
Deoxycytidine kinase
F5CTF3 [Target identity:100%; Query identity:100%]
Deoxynucleoside kinase
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004137 [deoxycytidine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006144 [purine nucleobase metabolic process]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0006220 [pyrimidine nucleotide metabolic process]
GO:0008144 [drug binding]
GO:0009157 [deoxyribonucleoside monophosphate biosynthetic process]
GO:0009165 [nucleotide biosynthetic process]
GO:0016310 [phosphorylation]
GO:0019206 [nucleoside kinase activity]
GO:0042803 [protein homodimerization activity]
GO:0043097 [pyrimidine nucleoside salvage]
GO:0043101 [purine-containing compound salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
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 260 aa
30.5 kDa 		No 0
DCK-004
ENSP00000425578
ENST00000504730
D6RCP9 [Direct mapping]
Deoxycytidine kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0009165 [nucleotide biosynthetic process]
GO:0019206 [nucleoside kinase activity]
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 199 aa
22.9 kDa 		No 0
DCK-005
ENSP00000421508
ENST00000504952
D6RFG8 [Direct mapping]
Deoxycytidine kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 317 aa
36.8 kDa 		No 0
DCK-006
ENSP00000422971
ENST00000509617
D6R9C6 [Direct mapping]
Deoxycytidine kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 15 aa
1.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.