Cell atlas - CD109 - The Human Protein Atlas

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CD109

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CD109
Gene description	CD109 molecule
Protein class	CD markers Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (ASC TERT1, BJ hTERT+)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (ASC TERT1, BJ hTERT+) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CD109 (HGNC Symbol)
Synonyms	CPAMD7, DKFZp762L1111, FLJ38569
Description	CD109 molecule (HGNC Symbol)
Entrez gene summary	This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Chromosome	6
Cytoband	q13
Chromosome location (bp)	73695785 - 73828316
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156535 (version 83.38)
Entrez gene	135228
UniProt	Q6YHK3 (UniProt - Evidence at protein level)
neXtProt	NX_Q6YHK3
Antibodypedia	CD109 antibodies

PROTEIN BROWSER

CD109-001	CD109-201	CD109-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD109-001 ENSP00000287097 ENST00000287097	Q6YHK3 [Direct mapping] CD109 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001933 [negative regulation of protein phosphorylation] GO:0001942 [hair follicle development] GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0009986 [cell surface] GO:0010839 [negative regulation of keratinocyte proliferation] GO:0010951 [negative regulation of endopeptidase activity] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0031225 [anchored component of membrane] GO:0045616 [regulation of keratinocyte differentiation] GO:0050431 [transforming growth factor beta binding] GO:0061045 [negative regulation of wound healing] GO:0072675 [osteoclast fusion] Show all	1445 aa 161.7 kDa	Yes	1
CD109-201 ENSP00000404475 ENST00000422508	Q6YHK3 [Direct mapping] CD109 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0009986 [cell surface] GO:0010951 [negative regulation of endopeptidase activity] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0031225 [anchored component of membrane] GO:0050431 [transforming growth factor beta binding] GO:0061045 [negative regulation of wound healing] Show all	1368 aa 152.7 kDa	Yes	1
CD109-202 ENSP00000388062 ENST00000437994	Q6YHK3 [Direct mapping] CD109 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0009986 [cell surface] GO:0010951 [negative regulation of endopeptidase activity] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0031225 [anchored component of membrane] GO:0050431 [transforming growth factor beta binding] GO:0061045 [negative regulation of wound healing] Show all	1428 aa 159.7 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.