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CD109

GENERAL INFORMATION

Gene name

 CD109

Gene description

 CD109 molecule

Protein class

 CD markers
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1, BJ hTERT+)
HPA (normal tissue):Tissue enriched (parathyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in a few tissues including parathyroid gland.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA009292 , HPA015113
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PROGNOSTIC SUMMARY
Prognostic marker in stomach cancer (unfavourable), renal cancer (unfavourable) and urothelial cancer (unfavourable).
Stomach cancer p<0.001
Renal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA009292
HPA015113

GENE INFORMATION

Gene name

 CD109 (HGNC Symbol)

Synonyms

 CPAMD7, DKFZp762L1111, FLJ38569

Description

 CD109 molecule (HGNC Symbol)

Entrez gene summary

 This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

Chromosome

 6

Cytoband

 q13

Chromosome location (bp)

 73695785 - 73828316

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156535 (version 83.38)

Entrez gene

 135228

UniProt

 Q6YHK3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6YHK3

Antibodypedia

 CD109 antibodies

PROTEIN BROWSER
CD109-001
CD109-201
CD109-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD109-001
ENSP00000287097
ENST00000287097
Q6YHK3 [Direct mapping]
CD109 antigen
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001933 [negative regulation of protein phosphorylation]
GO:0001942 [hair follicle development]
GO:0004866 [endopeptidase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0009986 [cell surface]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031225 [anchored component of membrane]
GO:0045616 [regulation of keratinocyte differentiation]
GO:0050431 [transforming growth factor beta binding]
GO:0061045 [negative regulation of wound healing]
GO:0072675 [osteoclast fusion]
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 1445 aa
161.7 kDa 		Yes 1
CD109-201
ENSP00000404475
ENST00000422508
Q6YHK3 [Direct mapping]
CD109 antigen
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004866 [endopeptidase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0009986 [cell surface]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031225 [anchored component of membrane]
GO:0050431 [transforming growth factor beta binding]
GO:0061045 [negative regulation of wound healing]
Show all
 1368 aa
152.7 kDa 		Yes 1
CD109-202
ENSP00000388062
ENST00000437994
Q6YHK3 [Direct mapping]
CD109 antigen
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004866 [endopeptidase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0009986 [cell surface]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031225 [anchored component of membrane]
GO:0050431 [transforming growth factor beta binding]
GO:0061045 [negative regulation of wound healing]
Show all
 1428 aa
159.7 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.