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CD109

GENERAL INFORMATION

Gene name

 CD109

Gene description

 CD109 molecule

Protein class

 CD markers
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (parathyroid gland)
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in a few tissues including parathyroid gland.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA009292 , HPA015113
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Parathyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 CD109 (HGNC Symbol)

Synonyms

 CPAMD7, DKFZp762L1111, FLJ38569

Description

 CD109 molecule (HGNC Symbol)

Entrez gene summary

 This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

Chromosome

 6

Cytoband

 q13

Chromosome location (bp)

 73695785 - 73828316

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156535 (version 83.38)

Entrez gene

 135228

UniProt

 Q6YHK3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6YHK3

Antibodypedia

 CD109 antibodies

PROTEIN BROWSER
CD109-001
CD109-201
CD109-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD109-001
ENSP00000287097
ENST00000287097
Q6YHK3 [Direct mapping]
CD109 antigen
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001942 [hair follicle development]
GO:0004866 [endopeptidase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0009986 [cell surface]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031225 [anchored component of membrane]
GO:0045616 [regulation of keratinocyte differentiation]
GO:0050431 [transforming growth factor beta binding]
GO:0061045 [negative regulation of wound healing]
GO:0072675 [osteoclast fusion]
Show all
 1445 aa
161.7 kDa 		Yes 1
CD109-201
ENSP00000404475
ENST00000422508
Q6YHK3 [Direct mapping]
CD109 antigen
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004866 [endopeptidase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0009986 [cell surface]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031225 [anchored component of membrane]
GO:0050431 [transforming growth factor beta binding]
GO:0061045 [negative regulation of wound healing]
Show all
 1368 aa
152.7 kDa 		Yes 1
CD109-202
ENSP00000388062
ENST00000437994
Q6YHK3 [Direct mapping]
CD109 antigen
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004866 [endopeptidase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0009986 [cell surface]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031225 [anchored component of membrane]
GO:0050431 [transforming growth factor beta binding]
GO:0061045 [negative regulation of wound healing]
Show all
 1428 aa
159.7 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.