Expression of SPPL3 in cancer - Summary

GENERAL INFORMATION
Gene name	SPPL3
Gene description	Signal peptide peptidase like 3
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern mainly in testis and the gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, Splice and/or transcript discrepancy exists. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA059958
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA059958

GENE INFORMATION
Gene name	SPPL3 (HGNC Symbol)
Synonyms	DKFZP586C1324, IMP2, MGC126674, MGC126676, MGC90402, PSL4
Description	Signal peptide peptidase like 3 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	120762510 - 120904371
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157837 (version 83.38)
Entrez gene	121665
UniProt	Q8TCT6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TCT6
Antibodypedia	SPPL3 antibodies

PROTEIN BROWSER

SPPL3-001	SPPL3-003	SPPL3-005	SPPL3-006	SPPL3-008	SPPL3-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPPL3-001 ENSP00000288680 ENST00000353487	Q8TCT6 [Direct mapping] Signal peptide peptidase-like 3 Show all	Enzymes Peptidases Aspartic-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0005515 [protein binding] GO:0005791 [rough endoplasmic reticulum] GO:0005829 [cytosol] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030660 [Golgi-associated vesicle membrane] GO:0032092 [positive regulation of protein binding] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0033619 [membrane protein proteolysis] GO:0035307 [positive regulation of protein dephosphorylation] GO:0042500 [aspartic endopeptidase activity, intramembrane cleaving] GO:0042803 [protein homodimerization activity] GO:0050852 [T cell receptor signaling pathway] GO:0051533 [positive regulation of NFAT protein import into nucleus] GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade] GO:0071458 [integral component of cytoplasmic side of endoplasmic reticulum membrane] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] Show all	384 aa 42.3 kDa	No	9
SPPL3-003 ENSP00000442484 ENST00000536996	F5H7J2 [Direct mapping] Signal peptide peptidase-like 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	183 aa 20.2 kDa	No	5
SPPL3-005 ENSP00000437603 ENST00000543608	F5H6I1 [Direct mapping] Signal peptide peptidase-like 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	164 aa 17.9 kDa	No	4
SPPL3-006 ENSP00000446088 ENST00000543181	F5H4L1 [Direct mapping] Signal peptide peptidase-like 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	118 aa 12.9 kDa	No	2
SPPL3-008 ENSP00000444821 ENST00000540091	F5H4Y6 [Direct mapping] Signal peptide peptidase-like 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	66 aa 7.2 kDa	No	1
SPPL3-009 ENSP00000439390 ENST00000543854	F5H2A2 [Direct mapping] Signal peptide peptidase-like 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	102 aa 11.3 kDa	No	1