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Gene name

Class

Subclass

Chromosome

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In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

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Searches

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Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

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Score

Score

Score

Antibodies

Column

 
 
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SPPL3
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

SPPL3

Gene description

Signal peptide peptidase like 3

Protein class

Enzymes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression with a granular pattern mainly in testis and the gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

Caution, Splice and/or transcript discrepancy exists. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA059958
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

SPPL3 (HGNC Symbol)

Synonyms

DKFZP586C1324, IMP2, MGC126674, MGC126676, MGC90402, PSL4

Description

Signal peptide peptidase like 3 (HGNC Symbol)

Entrez gene summary

Chromosome

12

Cytoband

q24.31

Chromosome location (bp)

120762510 - 120904371

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000157837 (version 83.38)

Entrez gene

121665

UniProt

Q8TCT6 (UniProt - Evidence at protein level)

neXtProt

NX_Q8TCT6

Antibodypedia

SPPL3 antibodies

PROTEIN BROWSER

SPPL3-001
SPPL3-003
SPPL3-005
SPPL3-006
SPPL3-008
SPPL3-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPPL3-001
ENSP00000288680
ENST00000353487
Q8TCT6 [Direct mapping]
Signal peptide peptidase-like 3
Show all
Enzymes
   Peptidases
   Aspartic-type peptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Show all
GO:0004190 [aspartic-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005791 [rough endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030660 [Golgi-associated vesicle membrane]
GO:0032092 [positive regulation of protein binding]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0033619 [membrane protein proteolysis]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0042500 [aspartic endopeptidase activity, intramembrane cleaving]
GO:0042803 [protein homodimerization activity]
GO:0050852 [T cell receptor signaling pathway]
GO:0051533 [positive regulation of NFAT protein import into nucleus]
GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade]
GO:0071458 [integral component of cytoplasmic side of endoplasmic reticulum membrane]
GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
Show all
384 aa
42.3 kDa
No 9
SPPL3-003
ENSP00000442484
ENST00000536996
F5H7J2 [Direct mapping]
Signal peptide peptidase-like 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0004190 [aspartic-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0016021 [integral component of membrane]
Show all
183 aa
20.2 kDa
No 5
SPPL3-005
ENSP00000437603
ENST00000543608
F5H6I1 [Direct mapping]
Signal peptide peptidase-like 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0004190 [aspartic-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0016021 [integral component of membrane]
Show all
164 aa
17.9 kDa
No 4
SPPL3-006
ENSP00000446088
ENST00000543181
F5H4L1 [Direct mapping]
Signal peptide peptidase-like 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0004190 [aspartic-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0016021 [integral component of membrane]
Show all
118 aa
12.9 kDa
No 2
SPPL3-008
ENSP00000444821
ENST00000540091
F5H4Y6 [Direct mapping]
Signal peptide peptidase-like 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004190 [aspartic-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0016021 [integral component of membrane]
Show all
66 aa
7.2 kDa
No 1
SPPL3-009
ENSP00000439390
ENST00000543854
F5H2A2 [Direct mapping]
Signal peptide peptidase-like 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004190 [aspartic-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0016021 [integral component of membrane]
Show all
102 aa
11.3 kDa
No 1

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The Human Protein Atlas project is funded
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