Cell atlas - CUL4B - The Human Protein Atlas

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CUL4B

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS GFP MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CUL4B
Gene description	Cullin 4B
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
GFP	The location(s) are Validated based on analysis of GFP-tagged protein.
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 3 antibodies. HPA003046 , HPA011880 , HPA058979
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA011880	U-2 OS	Nucleoplasm
	HPA011880	U-251 MG	Nucleoplasm
	HPA003046	A-431	Nucleoplasm
	HPA003046	A-431	Cytosol
	HPA003046	U-2 OS	Nucleoplasm
	HPA003046	U-2 OS	Cytosol
	HPA003046	U-251 MG	Nucleoplasm
	HPA003046	U-251 MG	Cytosol
	HPA058979	A-431	Nucleoplasm
	HPA058979	U-2 OS	Nucleoplasm
	HPA058979	U-251 MG	Nucleoplasm

GFP

Antibody	HPA003046
Validation	C-terminal tag BAC cell line: 3316 Validated: Antibody staining overlaps with GFP tagged protein

Antibody	HPA011880
Validation	C-terminal tag BAC cell line: 3316 Validated: Antibody staining overlaps with GFP tagged protein


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	BAC id	Tag	Location antibody staining	Location tagged protein
	HPA003046	HeLa	3316	C-terminal	Nucleoplasm	Nucleoplasm
	HPA003046	HeLa	Normal	-	Nucleoplasm, Cytosol	-
	HPA011880	HeLa	3316	C-terminal	Nucleoplasm	Nucleoplasm
	HPA011880	HeLa	Normal	-	Nucleoplasm, Vesicles	-

MOUSE CELLS

Main location

Nucleoplasm

Mouse gene

ENSMUSG00000031095 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA011880	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	CUL4B
Synonyms
Description	Cullin 4B (HGNC Symbol)
Entrez gene summary	This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q24
Chromosome location (bp)	120524609 - 120575794
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158290 (version 83.38)
Entrez gene	8450
UniProt	Q13620 (UniProt - Evidence at protein level)
neXtProt	NX_Q13620
Antibodypedia	CUL4B antibodies

PROTEIN BROWSER

CUL4B-001	CUL4B-003	CUL4B-004	CUL4B-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CUL4B-001 ENSP00000384109 ENST00000404115	Q13620 [Direct mapping] Cullin-4B Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000715 [nucleotide-excision repair, DNA damage recognition] GO:0003684 [damaged DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007049 [cell cycle] GO:0019985 [translesion synthesis] GO:0031175 [neuron projection development] GO:0031461 [cullin-RING ubiquitin ligase complex] GO:0031465 [Cul4B-RING E3 ubiquitin ligase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0033683 [nucleotide-excision repair, DNA incision] GO:0035518 [histone H2A monoubiquitination] GO:0042769 [DNA damage response, detection of DNA damage] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0045732 [positive regulation of protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] GO:0070062 [extracellular exosome] GO:0070911 [global genome nucleotide-excision repair] GO:0070914 [UV-damage excision repair] GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle] Show all	913 aa 104 kDa	No	0
CUL4B-003 ENSP00000360373 ENST00000371322	Q13620 [Direct mapping] Cullin-4B Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000715 [nucleotide-excision repair, DNA damage recognition] GO:0003684 [damaged DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007049 [cell cycle] GO:0019985 [translesion synthesis] GO:0031461 [cullin-RING ubiquitin ligase complex] GO:0031465 [Cul4B-RING E3 ubiquitin ligase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0033683 [nucleotide-excision repair, DNA incision] GO:0035518 [histone H2A monoubiquitination] GO:0042769 [DNA damage response, detection of DNA damage] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] GO:0070062 [extracellular exosome] GO:0070911 [global genome nucleotide-excision repair] GO:0070914 [UV-damage excision repair] Show all	895 aa 102.3 kDa	No	0
CUL4B-004 ENSP00000338919 ENST00000336592	K4DI93 [Direct mapping] Cullin 4B, isoform CRA_e; Cullin-4B Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0031461 [cullin-RING ubiquitin ligase complex] GO:0031625 [ubiquitin protein ligase binding] Show all	900 aa 102.8 kDa	No	0
CUL4B-007 ENSP00000360374 ENST00000371323	A6NE76 [Direct mapping] Cullin-4B Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0031625 [ubiquitin protein ligase binding] Show all	234 aa 27.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.