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Moderate to strong nuclear staining was observed in a few cases of most cancers. Cancer tissues in general showed weak nuclear staining or were negative.
Most cancer tissues showed moderate to strong nuclear with an additional cytoplasmic positivity in a few cases. Several hepatocellular carcinomas were weakly stained or negative.
GENE INFORMATION
Gene name
CUL4B
Synonyms
Description
Cullin 4B (HGNC Symbol)
Entrez gene summary
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000715 [nucleotide-excision repair, DNA damage recognition] GO:0003684 [damaged DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007049 [cell cycle] GO:0019985 [translesion synthesis] GO:0031175 [neuron projection development] GO:0031461 [cullin-RING ubiquitin ligase complex] GO:0031465 [Cul4B-RING E3 ubiquitin ligase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0033683 [nucleotide-excision repair, DNA incision] GO:0035518 [histone H2A monoubiquitination] GO:0042769 [DNA damage response, detection of DNA damage] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0045732 [positive regulation of protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] GO:0070062 [extracellular exosome] GO:0070911 [global genome nucleotide-excision repair] GO:0070914 [UV-damage excision repair] GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000715 [nucleotide-excision repair, DNA damage recognition] GO:0003684 [damaged DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007049 [cell cycle] GO:0019985 [translesion synthesis] GO:0031461 [cullin-RING ubiquitin ligase complex] GO:0031465 [Cul4B-RING E3 ubiquitin ligase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0033683 [nucleotide-excision repair, DNA incision] GO:0035518 [histone H2A monoubiquitination] GO:0042769 [DNA damage response, detection of DNA damage] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] GO:0070062 [extracellular exosome] GO:0070911 [global genome nucleotide-excision repair] GO:0070914 [UV-damage excision repair]