We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
KCNB1
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

KCNB1

Gene description

Potassium channel, voltage gated Shab related subfamily B, member 1

Protein class

Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (SCLC-21H, SK-BR-3, U-2 OS)
HPA (normal tissue):Tissue enhanced (adipose tissue, cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in neurons.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 2 antibodies.
HPA042434 , CAB001979
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY

HPA042434
CAB001979

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few colorectal cancers showed weak to moderate membranous staining. Remaining cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of breasts, renal, stomach and ovarian cancers showed weak membranous and cytoplasmic staining. Colorectal and testis cancers exhibited weak membranous positivity while few cases of pancreatic cancers showed moderate staining. Several cases of melanoma displayed weak cytoplasmic immunoreactivity. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

KCNB1 (HGNC Symbol)

Synonyms

Kv2.1

Description

Potassium channel, voltage gated Shab related subfamily B, member 1 (HGNC Symbol)

Entrez gene summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q13.13

Chromosome location (bp)

49363877 - 49484297

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000158445 (version 83.38)

Entrez gene

3745

UniProt

Q14721 (UniProt - Evidence at protein level)

neXtProt

NX_Q14721

Antibodypedia

KCNB1 antibodies

PROTEIN BROWSER

KCNB1-001
KCNB1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNB1-001
ENSP00000360806
ENST00000371741
Q14721 [Direct mapping]
Potassium voltage-gated channel subfamily B member 1
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001508 [action potential]
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0007215 [glutamate receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0010701 [positive regulation of norepinephrine secretion]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016328 [lateral plasma membrane]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031669 [cellular response to nutrient levels]
GO:0032182 [ubiquitin-like protein binding]
GO:0032809 [neuronal cell body membrane]
GO:0033605 [positive regulation of catecholamine secretion]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042383 [sarcolemma]
GO:0042593 [glucose homeostasis]
GO:0043204 [perikaryon]
GO:0044281 [small molecule metabolic process]
GO:0044325 [ion channel binding]
GO:0045211 [postsynaptic membrane]
GO:0045956 [positive regulation of calcium ion-dependent exocytosis]
GO:0046676 [negative regulation of insulin secretion]
GO:0046982 [protein heterodimerization activity]
GO:0050796 [regulation of insulin secretion]
GO:0051260 [protein homooligomerization]
GO:0055085 [transmembrane transport]
GO:0071333 [cellular response to glucose stimulus]
GO:0071805 [potassium ion transmembrane transport]
GO:0072661 [protein targeting to plasma membrane]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0098900 [regulation of action potential]
GO:1900454 [positive regulation of long term synaptic depression]
GO:2000671 [regulation of motor neuron apoptotic process]
Show all
858 aa
95.9 kDa
No 6
KCNB1-002
ENSP00000489193
ENST00000635465
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005515 [protein binding]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0051260 [protein homooligomerization]
GO:0055085 [transmembrane transport]
Show all
858 aa
95.9 kDa
No 6

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.