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Gene name

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Chromosome

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In atlas

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Reliability

Reliability

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Validation

Method

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Method

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Searches

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Detectable

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Detectable

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Detectable

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KCNB1
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    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

KCNB1

Gene description

Potassium channel, voltage gated Shab related subfamily B, member 1

Protein class

Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (adipose tissue, cerebral cortex)
GTEx:Tissue enhanced (cerebral cortex)
FANTOM5:Tissue enhanced (retina)

Protein evidence

Evidence at protein level

Protein expression

Membranous expression in neurons.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 2 antibodies.
HPA042434 , CAB001979
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue, cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (retina)

GENE INFORMATION

Gene name

KCNB1 (HGNC Symbol)

Synonyms

Kv2.1

Description

Potassium channel, voltage gated Shab related subfamily B, member 1 (HGNC Symbol)

Entrez gene summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q13.13

Chromosome location (bp)

49363877 - 49484297

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000158445 (version 83.38)

Entrez gene

3745

UniProt

Q14721 (UniProt - Evidence at protein level)

neXtProt

NX_Q14721

Antibodypedia

KCNB1 antibodies

PROTEIN BROWSER

KCNB1-001
KCNB1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNB1-001
ENSP00000360806
ENST00000371741
Q14721 [Direct mapping]
Potassium voltage-gated channel subfamily B member 1
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001508 [action potential]
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0007215 [glutamate receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0010701 [positive regulation of norepinephrine secretion]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016328 [lateral plasma membrane]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031669 [cellular response to nutrient levels]
GO:0032182 [ubiquitin-like protein binding]
GO:0032809 [neuronal cell body membrane]
GO:0033605 [positive regulation of catecholamine secretion]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042383 [sarcolemma]
GO:0042593 [glucose homeostasis]
GO:0043204 [perikaryon]
GO:0044281 [small molecule metabolic process]
GO:0044325 [ion channel binding]
GO:0045211 [postsynaptic membrane]
GO:0045956 [positive regulation of calcium ion-dependent exocytosis]
GO:0046676 [negative regulation of insulin secretion]
GO:0046982 [protein heterodimerization activity]
GO:0050796 [regulation of insulin secretion]
GO:0051260 [protein homooligomerization]
GO:0055085 [transmembrane transport]
GO:0071333 [cellular response to glucose stimulus]
GO:0071805 [potassium ion transmembrane transport]
GO:0072661 [protein targeting to plasma membrane]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0098900 [regulation of action potential]
GO:1900454 [positive regulation of long term synaptic depression]
GO:2000671 [regulation of motor neuron apoptotic process]
Show all
858 aa
95.9 kDa
No 6
KCNB1-002
ENSP00000489193
ENST00000635465
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005515 [protein binding]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0051260 [protein homooligomerization]
GO:0055085 [transmembrane transport]
Show all
858 aa
95.9 kDa
No 6

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