Cell atlas - HTR6 - The Human Protein Atlas

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HTR6

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	HTR6
Gene description	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
Protein class	FDA approved drug targets G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	HTR6 (HGNC Symbol)
Synonyms	5-HT6, 5-HT6R
Description	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]
Chromosome	1
Cytoband	p36.13
Chromosome location (bp)	19665287 - 19679562
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158748 (version 83.38)
Entrez gene	3362
UniProt	P50406 (UniProt - Evidence at protein level)
neXtProt	NX_P50406
Antibodypedia	HTR6 antibodies

PROTEIN BROWSER

HTR6-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HTR6-001 ENSP00000289753 ENST00000289753	P50406 [Direct mapping] 5-hydroxytryptamine receptor 6 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Serotonin receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004969 [histamine receptor activity] GO:0004993 [serotonin receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005929 [cilium] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007210 [serotonin receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0016021 [integral component of membrane] GO:0021795 [cerebral cortex cell migration] GO:0032008 [positive regulation of TOR signaling] Show all	440 aa 47 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.