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HTR6

GENERAL INFORMATION

Gene name

 HTR6

Gene description

 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (renal cancer)
HPA (cell line):Cell line enhanced (SH-SY5Y)
HPA (normal tissue):Not detected

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 HTR6 (HGNC Symbol)

Synonyms

 5-HT6, 5-HT6R

Description

 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]

Chromosome

 1

Cytoband

 p36.13

Chromosome location (bp)

 19665287 - 19679562

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158748 (version 83.38)

Entrez gene

 3362

UniProt

 P50406 (UniProt - Evidence at protein level)

neXtProt

 NX_P50406

Antibodypedia

 HTR6 antibodies

PROTEIN BROWSER
HTR6-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HTR6-001
ENSP00000289753
ENST00000289753
P50406 [Direct mapping]
5-hydroxytryptamine receptor 6
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Serotonin receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
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GO:0004930 [G-protein coupled receptor activity]
GO:0004969 [histamine receptor activity]
GO:0004993 [serotonin receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005929 [cilium]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007210 [serotonin receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0016021 [integral component of membrane]
GO:0021795 [cerebral cortex cell migration]
GO:0032008 [positive regulation of TOR signaling]
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 440 aa
47 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.