Tissue expression of HTR6 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HTR6
Gene description	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
Protein class	FDA approved drug targets G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Not detected
GTEx:	Tissue enhanced (caudate, cerebral cortex)
FANTOM5:	Tissue enriched (caudate)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Not detected
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate, cerebral cortex)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (caudate)

GENE INFORMATION
Gene name	HTR6 (HGNC Symbol)
Synonyms	5-HT6, 5-HT6R
Description	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]
Chromosome	1
Cytoband	p36.13
Chromosome location (bp)	19665287 - 19679562
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158748 (version 83.38)
Entrez gene	3362
UniProt	P50406 (UniProt - Evidence at protein level)
neXtProt	NX_P50406
Antibodypedia	HTR6 antibodies

PROTEIN BROWSER

HTR6-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HTR6-001 ENSP00000289753 ENST00000289753	P50406 [Direct mapping] 5-hydroxytryptamine receptor 6 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Serotonin receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004969 [histamine receptor activity] GO:0004993 [serotonin receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005929 [cilium] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007210 [serotonin receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0016021 [integral component of membrane] GO:0021795 [cerebral cortex cell migration] GO:0032008 [positive regulation of TOR signaling] Show all	440 aa 47 kDa	No	7