We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
USF1
  • premium

    TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

USF1

Gene description

Upstream transcription factor 1

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA036233 , CAB001480
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), urothelial cancer (favourable) and head and neck cancer (favourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
Head and neck cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA036233
CAB001480

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues showed moderate nuclear staining. Papillary adenocarcinomas of thyroid along with few cases of gliomas, lymphomas, ovarian and urothelial cancers displayed strong positivity.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer cells displayed moderate to strong nuclear immunoreactivity. Strongest staining was observed in cervical cancers, while several renal- and pancreatic cancers were weakly positive.

GENE INFORMATION

Gene name

USF1 (HGNC Symbol)

Synonyms

bHLHb11, MLTFI, UEF

Description

Upstream transcription factor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013]

Chromosome

1

Cytoband

q23.3

Chromosome location (bp)

161039251 - 161045977

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000158773 (version 83.38)

Entrez gene

7391

UniProt

P22415 (UniProt - Evidence at protein level)

neXtProt

NX_P22415

Antibodypedia

USF1 antibodies

PROTEIN BROWSER

USF1-001
USF1-002
USF1-003
USF1-008
USF1-009
USF1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

USF1-001
ENSP00000357000
ENST00000368021
P22415 [Direct mapping]
Upstream stimulatory factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000430 [regulation of transcription from RNA polymerase II promoter by glucose]
GO:0000432 [positive regulation of transcription from RNA polymerase II promoter by glucose]
GO:0001666 [response to hypoxia]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006006 [glucose metabolic process]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0009411 [response to UV]
GO:0019086 [late viral transcription]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0032869 [cellular response to insulin stimulus]
GO:0042593 [glucose homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0043425 [bHLH transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0045990 [carbon catabolite regulation of transcription]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0051918 [negative regulation of fibrinolysis]
GO:0055088 [lipid homeostasis]
Show all
310 aa
33.5 kDa
No 0
USF1-002
ENSP00000356999
ENST00000368020
P22415 [Direct mapping]
Upstream stimulatory factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000430 [regulation of transcription from RNA polymerase II promoter by glucose]
GO:0000432 [positive regulation of transcription from RNA polymerase II promoter by glucose]
GO:0001666 [response to hypoxia]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0009411 [response to UV]
GO:0019086 [late viral transcription]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0032869 [cellular response to insulin stimulus]
GO:0042593 [glucose homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0043425 [bHLH transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0045990 [carbon catabolite regulation of transcription]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0051918 [negative regulation of fibrinolysis]
GO:0055088 [lipid homeostasis]
Show all
310 aa
33.5 kDa
No 0
USF1-003
ENSP00000356998
ENST00000368019
B1AQP1 [Direct mapping]
Upstream stimulatory factor 1; Upstream transcription factor 1, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0046983 [protein dimerization activity]
Show all
282 aa
31 kDa
No 0
USF1-008
ENSP00000432533
ENST00000534633
E9PQA2 [Direct mapping]
Upstream stimulatory factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
106 aa
10.7 kDa
No 0
USF1-009
ENSP00000433041
ENST00000528768
H0YD59 [Direct mapping]
Upstream stimulatory factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046983 [protein dimerization activity]
Show all
165 aa
18.4 kDa
No 0
USF1-011
ENSP00000435005
ENST00000531842
E9PME6 [Direct mapping]
Upstream stimulatory factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0046983 [protein dimerization activity]
Show all
218 aa
24.1 kDa
No 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.