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USF1

GENERAL INFORMATION

Gene name

 USF1

Gene description

 Upstream transcription factor 1

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA036233 , CAB001480
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 USF1 (HGNC Symbol)

Synonyms

 bHLHb11, MLTFI, UEF

Description

 Upstream transcription factor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013]

Chromosome

 1

Cytoband

 q23.3

Chromosome location (bp)

 161039251 - 161045977

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158773 (version 83.38)

Entrez gene

 7391

UniProt

 P22415 (UniProt - Evidence at protein level)

neXtProt

 NX_P22415

Antibodypedia

 USF1 antibodies

PROTEIN BROWSER
USF1-001
USF1-002
USF1-003
USF1-008
USF1-009
USF1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
USF1-001
ENSP00000357000
ENST00000368021
P22415 [Direct mapping]
Upstream stimulatory factor 1
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000430 [regulation of transcription from RNA polymerase II promoter by glucose]
GO:0000432 [positive regulation of transcription from RNA polymerase II promoter by glucose]
GO:0001666 [response to hypoxia]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006006 [glucose metabolic process]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0009411 [response to UV]
GO:0019086 [late viral transcription]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0032869 [cellular response to insulin stimulus]
GO:0042593 [glucose homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0043425 [bHLH transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0045990 [carbon catabolite regulation of transcription]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0051918 [negative regulation of fibrinolysis]
GO:0055088 [lipid homeostasis]
Show all
 310 aa
33.5 kDa 		No 0
USF1-002
ENSP00000356999
ENST00000368020
P22415 [Direct mapping]
Upstream stimulatory factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000430 [regulation of transcription from RNA polymerase II promoter by glucose]
GO:0000432 [positive regulation of transcription from RNA polymerase II promoter by glucose]
GO:0001666 [response to hypoxia]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0009411 [response to UV]
GO:0019086 [late viral transcription]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0032869 [cellular response to insulin stimulus]
GO:0042593 [glucose homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0043425 [bHLH transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0045990 [carbon catabolite regulation of transcription]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0051918 [negative regulation of fibrinolysis]
GO:0055088 [lipid homeostasis]
Show all
 310 aa
33.5 kDa 		No 0
USF1-003
ENSP00000356998
ENST00000368019
B1AQP1 [Direct mapping]
Upstream stimulatory factor 1; Upstream transcription factor 1, isoform CRA_b
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0046983 [protein dimerization activity]
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 282 aa
31 kDa 		No 0
USF1-008
ENSP00000432533
ENST00000534633
E9PQA2 [Direct mapping]
Upstream stimulatory factor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 106 aa
10.7 kDa 		No 0
USF1-009
ENSP00000433041
ENST00000528768
H0YD59 [Direct mapping]
Upstream stimulatory factor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046983 [protein dimerization activity]
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 165 aa
18.4 kDa 		No 0
USF1-011
ENSP00000435005
ENST00000531842
E9PME6 [Direct mapping]
Upstream stimulatory factor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0046983 [protein dimerization activity]
Show all
 218 aa
24.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.