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GIP

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GENERAL INFORMATION

Gene name

 GIP

Gene description

 Gastric inhibitory polypeptide

Protein class

 Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (Hep G2, A549, BEWO)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2, A549, BEWO)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 GIP

Synonyms

Description

 Gastric inhibitory polypeptide (HGNC Symbol)

Entrez gene summary

 This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.32

Chromosome location (bp)

 48958554 - 48968596

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159224 (version 83.38)

Entrez gene

 2695

UniProt

 P09681 (UniProt - Evidence at protein level)

neXtProt

 NX_P09681

Antibodypedia

 GIP antibodies

PROTEIN BROWSER
GIP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GIP-001
ENSP00000350005
ENST00000357424
P09681 [Direct mapping]
Gastric inhibitory polypeptide
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005788 [endoplasmic reticulum lumen]
GO:0007165 [signal transduction]
GO:0007565 [female pregnancy]
GO:0007613 [memory]
GO:0008344 [adult locomotory behavior]
GO:0009743 [response to carbohydrate]
GO:0009749 [response to glucose]
GO:0010269 [response to selenium ion]
GO:0010447 [response to acidic pH]
GO:0010828 [positive regulation of glucose transport]
GO:0014070 [response to organic cyclic compound]
GO:0019233 [sensory perception of pain]
GO:0031018 [endocrine pancreas development]
GO:0031667 [response to nutrient levels]
GO:0032024 [positive regulation of insulin secretion]
GO:0033993 [response to lipid]
GO:0034774 [secretory granule lumen]
GO:0035640 [exploration behavior]
GO:0042493 [response to drug]
GO:0042594 [response to starvation]
GO:0043025 [neuronal cell body]
GO:0043200 [response to amino acid]
GO:0043434 [response to peptide hormone]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0044267 [cellular protein metabolic process]
GO:0048678 [response to axon injury]
GO:0050796 [regulation of insulin secretion]
GO:0050806 [positive regulation of synaptic transmission]
GO:0055123 [digestive system development]
GO:0060291 [long-term synaptic potentiation]
GO:0070094 [positive regulation of glucagon secretion]
GO:0070328 [triglyceride homeostasis]
Show all
 153 aa
17.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.