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Gene name

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In atlas

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Reliability

Reliability

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Validation

Method

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Searches

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Cancer

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Detectable

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GIP
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    TISSUE

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

GIP

Gene description

Gastric inhibitory polypeptide

Protein class

Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (duodenum, small intestine)
GTEx:Tissue enhanced (small intestine)
FANTOM5:Group enriched (colon, small intestine)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in a subset of cells in gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA021612 , CAB016729
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (duodenum, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, small intestine)

GENE INFORMATION

Gene name

GIP

Synonyms

Description

Gastric inhibitory polypeptide (HGNC Symbol)

Entrez gene summary

This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q21.32

Chromosome location (bp)

48958554 - 48968596

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159224 (version 83.38)

Entrez gene

2695

UniProt

P09681 (UniProt - Evidence at protein level)

neXtProt

NX_P09681

Antibodypedia

GIP antibodies

PROTEIN BROWSER

GIP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GIP-001
ENSP00000350005
ENST00000357424
P09681 [Direct mapping]
Gastric inhibitory polypeptide
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005788 [endoplasmic reticulum lumen]
GO:0007165 [signal transduction]
GO:0007565 [female pregnancy]
GO:0007613 [memory]
GO:0008344 [adult locomotory behavior]
GO:0009743 [response to carbohydrate]
GO:0009749 [response to glucose]
GO:0010269 [response to selenium ion]
GO:0010447 [response to acidic pH]
GO:0010828 [positive regulation of glucose transport]
GO:0014070 [response to organic cyclic compound]
GO:0019233 [sensory perception of pain]
GO:0031018 [endocrine pancreas development]
GO:0031667 [response to nutrient levels]
GO:0032024 [positive regulation of insulin secretion]
GO:0033993 [response to lipid]
GO:0034774 [secretory granule lumen]
GO:0035640 [exploration behavior]
GO:0042493 [response to drug]
GO:0042594 [response to starvation]
GO:0043025 [neuronal cell body]
GO:0043200 [response to amino acid]
GO:0043434 [response to peptide hormone]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0044267 [cellular protein metabolic process]
GO:0048678 [response to axon injury]
GO:0050796 [regulation of insulin secretion]
GO:0050806 [positive regulation of synaptic transmission]
GO:0055123 [digestive system development]
GO:0060291 [long-term synaptic potentiation]
GO:0070094 [positive regulation of glucagon secretion]
GO:0070328 [triglyceride homeostasis]
Show all
153 aa
17.1 kDa
Yes 0

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