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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

GIP

Gene description

Gastric inhibitory polypeptide

Protein class

Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (testis cancer)
HPA (cell line):Cell line enhanced (A549, BEWO, Hep G2)
HPA (normal tissue):Group enriched (duodenum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in a subset of cells in gastrointestinal tract.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA021612 , CAB016729
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA021612
CAB016729

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong cytoplasmic positivity was observed in several cases of hepatocellular carcinomas, pancreatic, gastric, colorectal and ovarian cancers. Other malignancies were in general weakly stained or negative.

GENE INFORMATION

Gene name

GIP

Synonyms

Description

Gastric inhibitory polypeptide (HGNC Symbol)

Entrez gene summary

This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q21.32

Chromosome location (bp)

48958554 - 48968596

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159224 (version 83.38)

Entrez gene

2695

UniProt

P09681 (UniProt - Evidence at protein level)

neXtProt

NX_P09681

Antibodypedia

GIP antibodies

PROTEIN BROWSER

GIP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GIP-001
ENSP00000350005
ENST00000357424
P09681 [Direct mapping]
Gastric inhibitory polypeptide
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005788 [endoplasmic reticulum lumen]
GO:0007165 [signal transduction]
GO:0007565 [female pregnancy]
GO:0007613 [memory]
GO:0008344 [adult locomotory behavior]
GO:0009743 [response to carbohydrate]
GO:0009749 [response to glucose]
GO:0010269 [response to selenium ion]
GO:0010447 [response to acidic pH]
GO:0010828 [positive regulation of glucose transport]
GO:0014070 [response to organic cyclic compound]
GO:0019233 [sensory perception of pain]
GO:0031018 [endocrine pancreas development]
GO:0031667 [response to nutrient levels]
GO:0032024 [positive regulation of insulin secretion]
GO:0033993 [response to lipid]
GO:0034774 [secretory granule lumen]
GO:0035640 [exploration behavior]
GO:0042493 [response to drug]
GO:0042594 [response to starvation]
GO:0043025 [neuronal cell body]
GO:0043200 [response to amino acid]
GO:0043434 [response to peptide hormone]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0044267 [cellular protein metabolic process]
GO:0048678 [response to axon injury]
GO:0050796 [regulation of insulin secretion]
GO:0050806 [positive regulation of synaptic transmission]
GO:0055123 [digestive system development]
GO:0060291 [long-term synaptic potentiation]
GO:0070094 [positive regulation of glucagon secretion]
GO:0070328 [triglyceride homeostasis]
Show all
153 aa
17.1 kDa
Yes 0

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