Tissue expression of ATP13A2 - Summary - The Human Protein Atlas

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ATP13A2

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ATP13A2
Gene description	ATPase type 13A2
Protein class	Disease related genes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression at varying levels, most abundant in CNS.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 4 antibodies. HPA050910 , HPA054717 , CAB037038 , CAB037111
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ATP13A2 (HGNC Symbol)
Synonyms	CLN12, HSA9947, PARK9
Description	ATPase type 13A2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2008]
Chromosome	1
Cytoband	p36.13
Chromosome location (bp)	16985958 - 17011928
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159363 (version 83.38)
Entrez gene	23400
UniProt	Q9NQ11 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQ11
Antibodypedia	ATP13A2 antibodies

PROTEIN BROWSER

ATP13A2-001	ATP13A2-002	ATP13A2-005	ATP13A2-007	ATP13A2-008	ATP13A2-009	ATP13A2-010	ATP13A2-011	ATP13A2-012	ATP13A2-014	ATP13A2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP13A2-001 ENSP00000327214 ENST00000326735	Q9NQ11 [Direct mapping] Probable cation-transporting ATPase 13A2 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005887 [integral component of plasma membrane] GO:0006812 [cation transport] GO:0006874 [cellular calcium ion homeostasis] GO:0008152 [metabolic process] GO:0012506 [vesicle membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0019829 [cation-transporting ATPase activity] GO:0034220 [ion transmembrane transport] GO:0043202 [lysosomal lumen] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0071287 [cellular response to manganese ion] GO:0098655 [cation transmembrane transport] Show all	1180 aa 128.8 kDa	No	>9
ATP13A2-002 ENSP00000341115 ENST00000341676	Q9NQ11 [Direct mapping] Probable cation-transporting ATPase 13A2 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005887 [integral component of plasma membrane] GO:0006812 [cation transport] GO:0006874 [cellular calcium ion homeostasis] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0019829 [cation-transporting ATPase activity] GO:0034220 [ion transmembrane transport] GO:0043202 [lysosomal lumen] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0071287 [cellular response to manganese ion] GO:0098655 [cation transmembrane transport] Show all	1158 aa 126 kDa	No	9
ATP13A2-005 ENSP00000413307 ENST00000452699	Q9NQ11 [Direct mapping] Probable cation-transporting ATPase 13A2 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005887 [integral component of plasma membrane] GO:0006812 [cation transport] GO:0006874 [cellular calcium ion homeostasis] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0019829 [cation-transporting ATPase activity] GO:0034220 [ion transmembrane transport] GO:0043202 [lysosomal lumen] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0071287 [cellular response to manganese ion] GO:0098655 [cation transmembrane transport] Show all	1175 aa 128.3 kDa	No	>9
ATP13A2-007 ENSP00000423065 ENST00000502418	H0Y953 [Direct mapping] Probable cation-transporting ATPase 13A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] Show all	398 aa 42.6 kDa	No	4
ATP13A2-008 ENSP00000422227 ENST00000508222	H0Y8V5 [Direct mapping] Probable cation-transporting ATPase 13A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	188 aa 21.5 kDa	No	1
ATP13A2-009 ENSP00000424313 ENST00000510069	H0Y9K0 [Direct mapping] Probable cation-transporting ATPase 13A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0006812 [cation transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0046872 [metal ion binding] Show all	321 aa 36 kDa	No	3
ATP13A2-010 ENSP00000422668 ENST00000509619	H0Y8Z6 [Direct mapping] Probable cation-transporting ATPase 13A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006812 [cation transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] Show all	191 aa 21.3 kDa	No	1
ATP13A2-011 ENSP00000427241 ENST00000511957	H0YAI7 [Direct mapping] Probable cation-transporting ATPase 13A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0016021 [integral component of membrane] GO:0046872 [metal ion binding] Show all	190 aa 21.6 kDa	No	1
ATP13A2-012 ENSP00000424393 ENST00000506174	H0Y9K4 [Direct mapping] Probable cation-transporting ATPase 13A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] Show all	191 aa 20.7 kDa	No	2
ATP13A2-014 ENSP00000421126 ENST00000503552	H0Y8I1 [Direct mapping] Probable cation-transporting ATPase 13A2 Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0046872 [metal ion binding] Show all	258 aa 28.1 kDa	No	0
ATP13A2-201 ENSP00000478781 ENST00000617114	A0A087WUM9 [Direct mapping] Probable cation-transporting ATPase 13A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] Show all	228 aa 24.5 kDa	No	2

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.