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CTBP1

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GENERAL INFORMATION

Gene name

 CTBP1

Gene description

 C-terminal binding protein 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

siRNA

 The location(s) are Validated based on siRNA mediated gene silencing.

GFP

 The location(s) are Validated based on analysis of GFP-tagged protein.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
CAB004217 , HPA018987
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ASSAYS
RNA expression
Human cells
siRNA
GFP

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA018987 A-431 Nucleoplasm
HPA018987 U-2 OS Nucleoplasm
HPA018987 U-251 MG Nucleoplasm
CAB004217 A-431 Nucleoplasm
CAB004217 U-2 OS Nucleoplasm
CAB004217 U-251 MG Nucleoplasm

siRNA VALIDATION

Antibody

 HPA018987

siRNA validation

 Validated: Significant downregulation > 25% by both siRNA:s.

Analysis performed in

 Nuclear region of segmented cells in 10x-images

siRNA 1

siRNA 2

RFI

 27%26%

p-value

 < 0.01< 0.01
 

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail 10x

Thumbnail 40x

Antibody

Sample

Cell line
HPA018987 siRNA 1 U-2 OS
HPA018987 siRNA 2 U-2 OS
HPA018987 scrambled U-2 OS

GFP

Antibody

 HPA018987

Validation

C-terminal tag
BAC cell line: 4639
Validated: Antibody staining overlaps with GFP tagged protein

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

BAC id

Tag

Location antibody staining

Location tagged protein
HPA018987 HeLa 4639 C-terminal Nucleoplasm Nucleoplasm
HPA018987 HeLa Normal - Nucleoplasm -

GENE INFORMATION

Gene name

 CTBP1 (HGNC Symbol)

Synonyms

 BARS

Description

 C-terminal binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p16.3

Chromosome location (bp)

 1211448 - 1249953

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159692 (version 83.38)

Entrez gene

 1487

UniProt

 Q13363 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13363

Antibodypedia

 CTBP1 antibodies

PROTEIN BROWSER
«
CTBP1-001
CTBP1-002
CTBP1-003
CTBP1-005
CTBP1-006
CTBP1-008
CTBP1-010
CTBP1-013
CTBP1-015
CTBP1-017
CTBP1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTBP1-001
ENSP00000290921
ENST00000290921
Q13363 [Direct mapping]
C-terminal-binding protein 1
X5D8Y5 [Target identity:100%; Query identity:100%]
C-terminal binding protein 1 isoform C
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0008022 [protein C-terminus binding]
GO:0008134 [transcription factor binding]
GO:0008152 [metabolic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0017053 [transcriptional repressor complex]
GO:0019079 [viral genome replication]
GO:0019904 [protein domain specific binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0035067 [negative regulation of histone acetylation]
GO:0042803 [protein homodimerization activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0050872 [white fat cell differentiation]
GO:0051287 [NAD binding]
GO:0051726 [regulation of cell cycle]
GO:0055114 [oxidation-reduction process]
GO:0070404 [NADH binding]
GO:0070491 [repressing transcription factor binding]
GO:0090241 [negative regulation of histone H4 acetylation]
GO:1903758 [negative regulation of transcription from RNA polymerase II promoter by histone modification]
Show all
 440 aa
47.5 kDa 		No 0
CTBP1-002
ENSP00000420983
ENST00000513420
E9PGB1 [Direct mapping]
C-terminal-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
Show all
 145 aa
15.9 kDa 		No 0
CTBP1-003
ENSP00000372411
ENST00000382952
Q13363 [Direct mapping]
C-terminal-binding protein 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0008022 [protein C-terminus binding]
GO:0008134 [transcription factor binding]
GO:0008152 [metabolic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0017053 [transcriptional repressor complex]
GO:0019079 [viral genome replication]
GO:0019904 [protein domain specific binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0035067 [negative regulation of histone acetylation]
GO:0042803 [protein homodimerization activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0050872 [white fat cell differentiation]
GO:0051287 [NAD binding]
GO:0051726 [regulation of cell cycle]
GO:0055114 [oxidation-reduction process]
GO:0070404 [NADH binding]
GO:0070491 [repressing transcription factor binding]
GO:0090241 [negative regulation of histone H4 acetylation]
GO:1903758 [negative regulation of transcription from RNA polymerase II promoter by histone modification]
Show all
 429 aa
46.4 kDa 		No 0
CTBP1-005
ENSP00000424684
ENST00000506180
D6RAX2 [Direct mapping]
C-terminal-binding protein 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
Show all
 187 aa
20.3 kDa 		No 0
CTBP1-006
ENSP00000425053
ENST00000515399
E7ESU7 [Direct mapping]
C-terminal-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
Show all
 171 aa
18.6 kDa 		No 0
CTBP1-008
ENSP00000423872
ENST00000510568
E7EUB3 [Direct mapping]
C-terminal-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 168 aa
18.1 kDa 		No 0
CTBP1-010
ENSP00000422364
ENST00000504092
H0Y8W7 [Direct mapping]
C-terminal-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
Show all
 287 aa
30.9 kDa 		No 0
CTBP1-013
ENSP00000426470
ENST00000514210
E7EPF8 [Direct mapping]
C-terminal-binding protein 1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
Show all
 202 aa
21.6 kDa 		No 0
CTBP1-015
ENSP00000422148
ENST00000503594
H0Y8U5 [Direct mapping]
C-terminal-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
Show all
 184 aa
19.4 kDa 		No 0
CTBP1-017
ENSP00000422730
ENST00000504784
H0Y913 [Direct mapping]
C-terminal-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 24 aa
2.5 kDa 		No 0
CTBP1-201
ENSP00000487417
ENST00000629223
A0A0D9SGE6 [Direct mapping]
C-terminal-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 69 aa
7.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.