Expression of CTBP1 in cancer - Summary - The Human Protein Atlas

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CTBP1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CTBP1
Gene description	C-terminal binding protein 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Approved based on 3 antibodies. HPA018987 , HPA044971 , CAB004217
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and urothelial cancer (favourable).
Endometrial cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018987	HPA044971	CAB004217

GENE INFORMATION
Gene name	CTBP1 (HGNC Symbol)
Synonyms	BARS
Description	C-terminal binding protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	1211448 - 1249953
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159692 (version 83.38)
Entrez gene	1487
UniProt	Q13363 (UniProt - Evidence at protein level)
neXtProt	NX_Q13363
Antibodypedia	CTBP1 antibodies

PROTEIN BROWSER

CTBP1-001	CTBP1-002	CTBP1-003	CTBP1-005	CTBP1-006	CTBP1-008	CTBP1-010	CTBP1-013	CTBP1-015	CTBP1-017	CTBP1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTBP1-001 ENSP00000290921 ENST00000290921	Q13363 [Direct mapping] C-terminal-binding protein 1 X5D8Y5 [Target identity:100%; Query identity:100%] C-terminal binding protein 1 isoform C Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001106 [RNA polymerase II transcription corepressor activity] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0008022 [protein C-terminus binding] GO:0008134 [transcription factor binding] GO:0008152 [metabolic process] GO:0008285 [negative regulation of cell proliferation] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0017053 [transcriptional repressor complex] GO:0019079 [viral genome replication] GO:0019904 [protein domain specific binding] GO:0031065 [positive regulation of histone deacetylation] GO:0035067 [negative regulation of histone acetylation] GO:0042803 [protein homodimerization activity] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0050872 [white fat cell differentiation] GO:0051287 [NAD binding] GO:0051726 [regulation of cell cycle] GO:0055114 [oxidation-reduction process] GO:0070404 [NADH binding] GO:0070491 [repressing transcription factor binding] GO:0090241 [negative regulation of histone H4 acetylation] GO:1903758 [negative regulation of transcription from RNA polymerase II promoter by histone modification] Show all	440 aa 47.5 kDa	No	0
CTBP1-002 ENSP00000420983 ENST00000513420	E9PGB1 [Direct mapping] C-terminal-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	145 aa 15.9 kDa	No	0
CTBP1-003 ENSP00000372411 ENST00000382952	Q13363 [Direct mapping] C-terminal-binding protein 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001106 [RNA polymerase II transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0008022 [protein C-terminus binding] GO:0008134 [transcription factor binding] GO:0008152 [metabolic process] GO:0008285 [negative regulation of cell proliferation] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0017053 [transcriptional repressor complex] GO:0019079 [viral genome replication] GO:0019904 [protein domain specific binding] GO:0031065 [positive regulation of histone deacetylation] GO:0035067 [negative regulation of histone acetylation] GO:0042803 [protein homodimerization activity] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0050872 [white fat cell differentiation] GO:0051287 [NAD binding] GO:0051726 [regulation of cell cycle] GO:0055114 [oxidation-reduction process] GO:0070404 [NADH binding] GO:0070491 [repressing transcription factor binding] GO:0090241 [negative regulation of histone H4 acetylation] GO:1903758 [negative regulation of transcription from RNA polymerase II promoter by histone modification] Show all	429 aa 46.4 kDa	No	0
CTBP1-005 ENSP00000424684 ENST00000506180	D6RAX2 [Direct mapping] C-terminal-binding protein 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	187 aa 20.3 kDa	No	0
CTBP1-006 ENSP00000425053 ENST00000515399	E7ESU7 [Direct mapping] C-terminal-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	171 aa 18.6 kDa	No	0
CTBP1-008 ENSP00000423872 ENST00000510568	E7EUB3 [Direct mapping] C-terminal-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		168 aa 18.1 kDa	No	0
CTBP1-010 ENSP00000422364 ENST00000504092	H0Y8W7 [Direct mapping] C-terminal-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	287 aa 30.9 kDa	No	0
CTBP1-013 ENSP00000426470 ENST00000514210	E7EPF8 [Direct mapping] C-terminal-binding protein 1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	202 aa 21.6 kDa	No	0
CTBP1-015 ENSP00000422148 ENST00000503594	H0Y8U5 [Direct mapping] C-terminal-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	184 aa 19.4 kDa	No	0
CTBP1-017 ENSP00000422730 ENST00000504784	H0Y913 [Direct mapping] C-terminal-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		24 aa 2.5 kDa	No	0
CTBP1-201 ENSP00000487417 ENST00000629223	A0A0D9SGE6 [Direct mapping] C-terminal-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		69 aa 7.5 kDa	No	0

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