Cell atlas - S100A1 - The Human Protein Atlas

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S100A1

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	S100A1
Gene description	S100 calcium binding protein A1
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (SK-MEL-30, Hep G2)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SK-MEL-30, Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	S100A1 (HGNC Symbol)
Synonyms	S100-alpha, S100A
Description	S100 calcium binding protein A1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	153627926 - 153632039
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160678 (version 83.38)
Entrez gene	6271
UniProt	P23297 (UniProt - Evidence at protein level)
neXtProt	NX_P23297
Antibodypedia	S100A1 antibodies

PROTEIN BROWSER

S100A1-001	S100A1-003	S100A1-004	S100A1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
S100A1-001 ENSP00000292169 ENST00000292169	P23297 [Direct mapping] Protein S100-A1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008016 [regulation of heart contraction] GO:0016529 [sarcoplasmic reticulum] GO:0021762 [substantia nigra development] GO:0030018 [Z disc] GO:0031430 [M band] GO:0031672 [A band] GO:0031674 [I band] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043005 [neuron projection] GO:0043234 [protein complex] GO:0044548 [S100 protein binding] GO:0048306 [calcium-dependent protein binding] GO:0051117 [ATPase binding] GO:1901387 [positive regulation of voltage-gated calcium channel activity] Show all	94 aa 10.5 kDa	No	0
S100A1-003 ENSP00000357687 ENST00000368698	Q5T7Y6 [Direct mapping] Protein S100 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0008016 [regulation of heart contraction] Show all	147 aa 15.9 kDa	No	0
S100A1-004 ENSP00000389708 ENST00000436839	Q5T7Y5 [Direct mapping] Protein S100-A1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0008016 [regulation of heart contraction] Show all	34 aa 3.8 kDa	No	0
S100A1-005 ENSP00000357685 ENST00000368696	Q5T7Y4 [Direct mapping] Protein S100-A1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0008016 [regulation of heart contraction] Show all	53 aa 6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.