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S100A1

GENERAL INFORMATION

Gene name

 S100A1

Gene description

 S100 calcium binding protein A1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (heart muscle, skeletal muscle)
FANTOM5:Tissue enhanced (heart muscle, salivary gland, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in several tissue types. Most abundant in CNS, salivary glands, melaocytes, skeletal and heart muscle.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA006462 , CAB002599
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (heart muscle, skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle, salivary gland, skeletal muscle)

GENE INFORMATION

Gene name

 S100A1 (HGNC Symbol)

Synonyms

 S100-alpha, S100A

Description

 S100 calcium binding protein A1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 153627926 - 153632039

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160678 (version 83.38)

Entrez gene

 6271

UniProt

 P23297 (UniProt - Evidence at protein level)

neXtProt

 NX_P23297

Antibodypedia

 S100A1 antibodies

PROTEIN BROWSER
S100A1-001
S100A1-003
S100A1-004
S100A1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
S100A1-001
ENSP00000292169
ENST00000292169
P23297 [Direct mapping]
Protein S100-A1
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0008016 [regulation of heart contraction]
GO:0016529 [sarcoplasmic reticulum]
GO:0021762 [substantia nigra development]
GO:0030018 [Z disc]
GO:0031430 [M band]
GO:0031672 [A band]
GO:0031674 [I band]
GO:0035556 [intracellular signal transduction]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0043234 [protein complex]
GO:0044548 [S100 protein binding]
GO:0048306 [calcium-dependent protein binding]
GO:0051117 [ATPase binding]
GO:1901387 [positive regulation of voltage-gated calcium channel activity]
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 94 aa
10.5 kDa 		No 0
S100A1-003
ENSP00000357687
ENST00000368698
Q5T7Y6 [Direct mapping]
Protein S100
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
GO:0008016 [regulation of heart contraction]
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 147 aa
15.9 kDa 		No 0
S100A1-004
ENSP00000389708
ENST00000436839
Q5T7Y5 [Direct mapping]
Protein S100-A1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
GO:0008016 [regulation of heart contraction]
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 34 aa
3.8 kDa 		No 0
S100A1-005
ENSP00000357685
ENST00000368696
Q5T7Y4 [Direct mapping]
Protein S100-A1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0008016 [regulation of heart contraction]
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 53 aa
6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.