Expression of S100A1 in cancer - Summary

GENERAL INFORMATION
Gene name	S100A1
Gene description	S100 calcium binding protein A1
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (melanoma, ovarian cancer, thyroid cancer)
HPA (cell line):	Cell line enhanced (Hep G2, SK-MEL-30)
HPA (normal tissue):	Group enriched (heart muscle, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissue types. Most abundant in CNS, salivary glands, melaocytes, skeletal and heart muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA006462 , CAB002599
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and renal cancer (unfavourable).
Endometrial cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (melanoma, ovarian cancer, thyroid cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA006462	CAB002599

GENE INFORMATION
Gene name	S100A1 (HGNC Symbol)
Synonyms	S100-alpha, S100A
Description	S100 calcium binding protein A1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	153627926 - 153632039
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160678 (version 83.38)
Entrez gene	6271
UniProt	P23297 (UniProt - Evidence at protein level)
neXtProt	NX_P23297
Antibodypedia	S100A1 antibodies

PROTEIN BROWSER

S100A1-001	S100A1-003	S100A1-004	S100A1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
S100A1-001 ENSP00000292169 ENST00000292169	P23297 [Direct mapping] Protein S100-A1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008016 [regulation of heart contraction] GO:0016529 [sarcoplasmic reticulum] GO:0021762 [substantia nigra development] GO:0030018 [Z disc] GO:0031430 [M band] GO:0031672 [A band] GO:0031674 [I band] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043005 [neuron projection] GO:0043234 [protein complex] GO:0044548 [S100 protein binding] GO:0048306 [calcium-dependent protein binding] GO:0051117 [ATPase binding] GO:1901387 [positive regulation of voltage-gated calcium channel activity] Show all	94 aa 10.5 kDa	No	0
S100A1-003 ENSP00000357687 ENST00000368698	Q5T7Y6 [Direct mapping] Protein S100 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0008016 [regulation of heart contraction] Show all	147 aa 15.9 kDa	No	0
S100A1-004 ENSP00000389708 ENST00000436839	Q5T7Y5 [Direct mapping] Protein S100-A1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0008016 [regulation of heart contraction] Show all	34 aa 3.8 kDa	No	0
S100A1-005 ENSP00000357685 ENST00000368696	Q5T7Y4 [Direct mapping] Protein S100-A1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0008016 [regulation of heart contraction] Show all	53 aa 6 kDa	No	0